Ann Dermatol.  2000 Jun;12(2):134-137. 10.5021/ad.2000.12.2.134.

Three Cases of Livedoid Vasculitis Improved by Low-dose Danazol

• Song MG
• Park SH
• Lee ES

• KMID: 2163966
• DOI: http://doi.org/10.5021/ad.2000.12.2.134

Abstract

Livedoid vasculitis is characterized clinically by smooth or depressed ivory-white scars surrounded by hyperpigmentation and telangiectasia with or without preceding purpuric in-filtrated papules and plaques and histologically by intravascular deposition of fibrin. Its pathophysiology is still obscure. Many treatment modalities have been used, but results are not satisfactory. Recently, there have been experiences of successful treatments with danazol, a synthetic androgen. We used danazol in three patients who presented with livedoid vasculitis and were relatively resistant to treatments with aspirin and/or pentoxifylline. After 4 to 8 weeks, there was remarkable clinical improvement in all three patients.

Keyword

Danazol; Livedoid vasculitis

MeSH Terms

Aspirin
Cicatrix
Danazol*
Fibrin
Humans
Hyperpigmentation
Pentoxifylline
Telangiectasis
Vasculitis*
Aspirin
Danazol
Fibrin
Pentoxifylline