Ann Dermatol.  2001 Mar;13(1):44-47. 10.5021/ad.2001.13.1.44.

Disappearing Atypical Lentiginous Pigmentation of the Desmoplastic Malignant Melanoma

• Lim SH
• Baek SC
• Byun DG
• Houh D

• KMID: 2163859
• DOI: http://doi.org/10.5021/ad.2001.13.1.44

Abstract

A 38-year-old man presented with a black pigmented patch overlying his upper lip, a part of the gingiva and the hard palate. An intradermal tumor mass was palpated at the central portion of the pigmented patch of the upper lip. Diphenylcyclopropenone (DPCP) is a potent contact sensitizer that could stimulate non-specific immunity. We report a case of desmoplastic malignant melanoma (DMM) in which an atypical lentiginous pigmentation disappeared with topical DPCP immunotherapy and the dermal tumor mass was removed by a surgical wedge-shaped excision. Though an atypical lentiginous pigmentation of DMM sometimes undergoes extensive spontaneous regression, in our case it could be attributed to the therapeutic effect of topical DPCP immunotherapy rather than a spontaneous regression.

Keyword

Diphenylcyclopropenone; desmoplastic malignant melanoma

MeSH Terms

Adult
Gingiva
Humans
Immunity, Innate
Immunotherapy
Lip
Melanoma*
Palate, Hard
Pigmentation*