Korean J Intern Med.  2016 May;31(3):488-500. 10.3904/kjim.2014.119.

Immediate multivessel revascularization may increase cardiac death and myocardial infarction in patients with ST-elevation myocardial infarction and multivessel coronary artery disease: data analysis from real world practice

• Chung WY
• Seo JB
• Choi DH
• Cho YS
• Lee JM
• Suh JW
• Youn TJ
• Chae IH
• Choi DJ

• KMID: 2163505
• DOI: http://doi.org/10.3904/kjim.2014.119

Abstract

BACKGROUND/AIMS
The best revascularization strategy for patients with both acute ST-elevation myocardial infarction (STEMI) and multivessel coronary disease (MVD) is still debatable. We aimed to compare the outcomes of multivessel revascularization (MVR) with those of culprit-only revascularization (COR).
METHODS
A cohort of 215 consecutive patients who had received primary angioplasty for STEMI and MVD were divided into two groups according to whether angioplasty had been also performed for a stenotic nonculprit artery. The primary endpoint was one-year major adverse cardiac events defined as a composite of cardiac death, recurrent myocardial infarction, or any repeat revascularization.
RESULTS
One-year major adverse cardiac events were not significantly different between MVR (n = 107) and COR (n = 108) groups. However, the one-year composite hard endpoint of cardiac death or recurrent myocardial infarction was notably increased in the MVR group compared to the COR group (20.0% vs. 8.9%, p = 0.024). In subgroup analysis, the hard endpoint was significantly more frequent in the immediate than in the staged MVR subgroup (26.6% vs. 9.8%, p = 0.036). The propensity score-matched cohorts confirmed these findings.
CONCLUSIONS
In patients with STEMI and MVD, MVR, especially immediate MVR with primary percutaneous intervention, was not beneficial and led to worse outcomes. Therefore, we conclude that COR or staged MVR would be better strategies for patients with STEMI and MVD.

Keyword

Myocardial infarction; Primary angioplasty; Coronary artery disease

MeSH Terms

Angioplasty
Arteries
Cohort Studies
Coronary Artery Disease*
Coronary Disease
Coronary Vessels*
Death*
Humans
Myocardial Infarction*