Korean J Gastroenterol.  2014 Sep;64(3):168-172. 10.4166/kjg.2014.64.3.168.

Synchronous Hepatocellular Carcinoma and B-Cell Non-Hodgkin's Lymphoma in Chronic Hepatitis C Patient

• Lee SI
• Heo NY
• Park SH
• Joo YD
• Kim IH
• Park JI
• Kim JY
• Kim SH
• Shim HK

• KMID: 2160660
• DOI: http://doi.org/10.4166/kjg.2014.64.3.168

Abstract

Hepatitis C virus (HCV) is one of the main viral causes of hepatocellular carcinoma (HCC) and is associated with lymphoproliferative disorder such as non-Hodgkin's lymphoma (NHL). However, there are only few case reports on concomitantly induced NHL and HCC by HCV. Herein, we report a case of synchronous NHL and HCC in a patient with chronic hepatitis C which was unexpectedly diagnosed during liver transplantation surgery. This case suggests that although intrahepatic lymph node enlargements are often considered as reactive or metastatic lymphadenopathy in chronic hepatitis C patients with HCC, NHL should also be considered as a differential diagnosis.

Keyword

Hepatocellular carcinoma; Hepatitis C; Non-Hodgkin lymphoma

MeSH Terms

Antineoplastic Agents/therapeutic use
Carcinoma, Hepatocellular/complications/*diagnosis/radiotherapy
Drug Therapy, Combination
Embolization, Therapeutic
Fluorodeoxyglucose F18
Gadolinium DTPA
Genotype
Hepatitis B virus/genetics
Hepatitis C, Chronic/complications/*diagnosis/*virology
Humans
Liver Neoplasms/complications/*diagnosis/radiotherapy
Lymph Nodes/pathology
Lymphoma, Non-Hodgkin/complications/*diagnosis/drug therapy
Magnetic Resonance Imaging
Male
Middle Aged
Positron-Emission Tomography
Tomography, X-Ray Computed
Antineoplastic Agents
Fluorodeoxyglucose F18
Gadolinium DTPA