Korean J Med.  1997 Oct;53(4):556-560.

A Case of Non-Hodgkin's Lymphoma Associated with Hepatocellular Carcinoma

• Sung JB
• Kim YC
• Kwun GS
• Jang EJ
• Ryoo BY
• Kim TY
• Im YH
• Kang YK
• Kim CM
• Lee SS
• Lee JO
• Kang TW

Abstract

Multiple primary malignant neoplasms (MPMN) are defined by the presence of multiple primary cancers of multicentric origin and/or different tissues. The incidence of MPMN is less than 1% in Korea and recently seems to be increased due to early detection of cancer and prolonged survival of cancer patients. Previous investigations suggest that non-Hodgkin's lymphoma (NHL) may be associated with chronic liver disease and hepatocellular carcinoma (HCC). The pathogenesis of this association is thought to be due to chronic antigenic stimulation, the presence of HBsAg, and immunosuppressive therapy. We report a case of synchronous NHL and HCC in a 54-year-old man which is thought to be associated with hepatitis B virus infection. Pathological examination and immunohistochemical study of neck lymph node and liver mass biopsies showed diffuse large cell lymphoma and HCC, respectively. He was treated initially with EPOCH (etoposide, vincristine, doxorubicin, cyclophosphamide and prednisolone) chemotherapy for NHL and transarterial chemoembolization with doxorubicin, mitomycin-c, lipiodol, and gelfoam for HCC.

Keyword

Non - Hodgkin's lymphoma; Hepatocellular carcinoma; Multiple primary cancer

MeSH Terms

Biopsy
Carcinoma, Hepatocellular*
Cyclophosphamide
Doxorubicin
Drug Therapy
Early Detection of Cancer
Ethiodized Oil
Gelatin Sponge, Absorbable
Hepatitis B Surface Antigens
Hepatitis B virus
Humans
Incidence
Korea
Liver
Liver Diseases
Lymph Nodes
Lymphoma, Large B-Cell, Diffuse
Lymphoma, Non-Hodgkin*
Middle Aged
Mitomycin
Neck
Vincristine
Cyclophosphamide
Doxorubicin
Ethiodized Oil
Hepatitis B Surface Antigens
Mitomycin
Vincristine