Gut Liver.  2015 Jul;9(4):470-477. 10.5009/gnl13263.

Endoscopic and Oncologic Outcomes of Endoscopic Resection for Superficial Esophageal Neoplasm

• Kim DH
• Jung HY
• Gong EJ
• Choi JY
• Ahn JY
• Kim MY
• Choi KS
• Lee JH
• Choi KD
• Song HJ
• Lee GH
• Kim JH
• Park YS
• Baek S

• KMID: 2160630
• DOI: http://doi.org/10.5009/gnl13263

Abstract

BACKGROUND/AIMS
Endoscopic resection (ER) of superficial esophageal neoplasm (SEN) is a technically difficult procedure. We investigated the clinical outcomes of ER for SEN to determine its feasibility and effectiveness.
METHODS
Subjects who underwent ER for SEN at Asan Medical Center between December 1996 and December 2010 were eligible. The clinical features of patients and tumors, histopathological characteristics, adverse events, ER results and survival were investigated.
RESULTS
A total of 129 patients underwent ER for 147 SENs. En bloc resection (EnR) was performed in 118 lesions (80.3%). Complete resection (CR) was accomplished in 128 lesions (86.5%), and curative resection (CuR) was performed in 118 lesions (79.7%). The EnR, CR, and CuR rates were significantly greater in the endoscopic submucosal dissection group when compared to those in the endoscopic resection group. Adverse events occurred in 22 patients (17.1%), including bleeding (n=2, 1.6%), perforation (n=12, 9.3%), and stricture (n=8, 6.2%). Local tumor recurrence occurred in 2.0% of patients during a median follow-up of 34.8 months. The 5-year overall and disease-specific survival rates were 94.0% and 97.5%, respectively.
CONCLUSIONS
ER is a feasible and effective method for the treatment of SEN as indicated by favorable clinical outcomes.

Keyword

Esophageal neoplasms; Treatment outcome; Endoscopic resection

MeSH Terms

Aged
Aged, 80 and over
Disease-Free Survival
Dissection/*adverse effects/methods
Esophageal Neoplasms/pathology/*surgery
Esophageal Perforation/epidemiology/etiology
Esophageal Stenosis/epidemiology/etiology
Esophagoscopy/*adverse effects/methods
Female
Gastric Mucosa/surgery
Humans
Male
Middle Aged
Neoplasm Recurrence, Local/epidemiology
Postoperative Hemorrhage/epidemiology/etiology
Retrospective Studies
Treatment Outcome