Obstet Gynecol Sci.  2016 Mar;59(2):116-122. 10.5468/ogs.2016.59.2.116.

Prognostic factors in neuroendocrine cervical carcinoma

  • 1Department of Obstetrics and Gynecology, Seoul National University Hospital, Seoul, Korea. marialeemd@gmail.com
  • 2Department of Obstetrics and Gynecology, Seoul National University College of Medicine, Seoul, Korea.
  • 3Center for Uterine Cancer, Research Institute and Hospital, National Cancer Center, Goyang, Korea.


To evaluate the clinical and pathologic factors associated with survival in patients with neuroendocrine cervical carcinoma (NECC).
The records of 61 patients with NECC diagnosed between 2000 and 2014 at Seoul National University Hospital and the National Cancer Center were retrospectively reviewed. Kaplan-Meier and Cox regression methods were used for analyses.
Of the 61 patients, 67.2% were diagnosed at early stage (I to IIA) with a median age of 49 years. Of those, 78% underwent surgery and 75.6% received postoperative adjuvant treatment. For patients diagnosed at advanced stage, 60.0% received chemotherapy only and 25.0% received concurrent chemoradiation therapy. In the univariate analysis, advanced stage (77 vs. 40 months, P=0.013), tumor size ≥2 cm (133 vs. 47 months, P=0.002) and mixed tumor (101 vs. 34 months, P=0.004) were shown to be poor prognostic factors. In the multivariate analysis, tumor stage, tumor size and tumor homology were shown to be independent prognostic factors for overall survival. Of the total, 39.3% of the patients experienced recurrence, and 54.1% of the patients had metastasis. Of the patients diagnosed at early stage, 51.2% experienced recurrence.
Tumor stage, tumor size and tumor homology were found to be independent prognostic factors in patients with NECC. Even in patients diagnosed at early stage, recurrence and distant metastasis were frequently observed.


Cervical carcinoma; Neoplasm recurrence; Neuroendocrine carcinoma; Retrospective studies; Small cell carcinoma

MeSH Terms

Carcinoma, Neuroendocrine
Carcinoma, Small Cell
Drug Therapy
Multivariate Analysis
Neoplasm Metastasis
Retrospective Studies


  • Fig. 1 Overall survival estimates stratified by (A) tumor stage, (B) tumor size in all stage, (C) tumor size in early stage, and (D) tumor homology.


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