Ann Dermatol.  2002 Jun;14(2):82-87. 10.5021/ad.2002.14.2.82.

Combination Therapy with Intralesional Interferon α-2b and Pulsed Dye Laser for the Treatment of Periungual Warts

• Choi GS
• Park JH
• Kim YK
• Choi GS

• KMID: 2158723
• DOI: http://doi.org/10.5021/ad.2002.14.2.82

Abstract

BACKGROUND
Periungual warts are a therapeutic challenge. Many studies have revealed that intralesional interferon α-2b therapy and pulsed dye laser therapy have numerous advantages over other modalities of theratment.
OBJECTIVE
The purpose of this study was to determine if combination therapy with intralesional interferon α-2b and pulsed dye laser might offer an effective treatment for periungual warts.
METHODS
Thirty-three patients were randomly assigned to one of three study groups. In group A, the patients received both intralesional interferon α-2b treatment and pulsed dye laser(PDL) therapy (n=13). Group B patients were treated wit intralesional interferon α-2b alone (n=10) and group C was done with PDL therapy only (n=10).
RESULTS
The clearance rate was 92.3% for the patients treated with the combination therapy of intralesional interferon α-2b treatment and pulsed dye laser (PDL) therapy. It was 50% for the patients with the intralesional interferon α-2b treatment alone, and 0% for the group with the PDL therpy only. No significant side effects were observed. At 6 months after cessation of the therapy, total 2 cases (one from group A and the other from group B) were recurred.
CONCLUSION
The combination therapy with intralesional interferon α-2b treatment and pulsed dye laser therapy was highly effective for the treatment of recalcitrant periungual warts.

Keyword

Combination therypy; Interferon α-2b; Periungual warts; Pulsed dye laser

MeSH Terms

Humans
Interferons*
Lasers, Dye*
Warts*
Interferons