J Korean Med Sci.  2013 Jun;28(6):876-880. 10.3346/jkms.2013.28.6.876.

Association between Metabolic Syndrome and Gallbladder Polyps in Healthy Korean Adults

• Park EJ
• Lee HS
• Lee SH
• Chun HJ
• Kim SY
• Choi YK
• Ryu HJ
• Shim KW

• KMID: 2158035
• DOI: http://doi.org/10.3346/jkms.2013.28.6.876

Abstract

The goal of this study was to evaluate the association between gallbladder (GB) polyps and metabolic syndrome. A total of 5,685 healthy subjects were included, and 485 of these subjects had GB polyps and 744 had metabolic syndrome. In this study, metabolic syndrome was diagnosed according to standards suggested by the AHA/NHLBI ATP III 2005, and abdominal obesity (> or = 90 cm in men and > or = 85 cm in women for Korean) was diagnosed according to standards set forth by the Korean Society for Study of Obesity. Biphasic logistic regression adjusted for age and gender was used to evaluate the association between metabolic syndrome and GB polyps. Subjects who were male (OR, 1.493; 95% CI, 1.11-2.00) and hepatitis B suface Ag (HBsAg) positive (OR, 1.591; 95% CI, 1.06-2.38) were significantly more likely to have GB polyps. The metabolic syndrome group had a higher risk of GB polyps (OR, 1.315; 95% CI, 1.01-1.69) than the group without metabolic syndrome. In conclusion, subjects who were HBsAg positive and male appear to be associated with the risk of GB polyps. The presence of metabolic syndrome also appears to be associated with the risk of GB polyps in Koreans.

Keyword

Metabolic Syndrome; GB Polyp; Risk Factors

MeSH Terms

Adult
Age Factors
Asian Continental Ancestry Group
Female
Gallbladder Diseases/*diagnosis/etiology
Hepatitis B Surface Antigens/blood
Humans
Logistic Models
Male
Metabolic Syndrome X/complications/*diagnosis
Middle Aged
Odds Ratio
Republic of Korea
Risk Factors
Severity of Illness Index
Sex Factors
Hepatitis B Surface Antigens

Reference

1. Fauci AS, Braunwald E, Kasper DL, Hauser SL, Longo DL, Jameson JL, Loscalzo J. Harrison's principles of internal medicine. 2008. 17th ed. New York: McGraw-Hill;1509–1514.

2. Lim S, Shin H, Song JH, Kwak SH, Kang SM, Won YJ, Choi SH, Cho SI, Park KS, Lee HK, et al. Increasing prevalence of metabolic syndrome in Korea: the Korean National Health and Nutrition Examination Survey for 1998-2007. Diabetes Care. 2011. 34:1323–1328.

3. Kim SM, Kim KM, Lee DJ. Relationship of uric acid concentration to free fat acid, cardiovascular risk factors and intraperitoneal fat. J Korean Soc Study Obes. 1997. 6:51–58.

4. Christensen AH, Ishak KG. Benign tumors and pseudotumors of the gallbladder: report of 180 cases. Arch Pathol. 1970. 90:423–432.

5. Kozuka S, Tsubone N, Yasui A, Hachisuka K. Relation of adenoma to carcinoma in the gallbladder. Cancer. 1982. 50:2226–2234.

6. Shim SG, Lee KT, Lee JK, Park JH, Ryu KH, Rhee PL, Kim JJ, Koh KC, Paik SW, Rhee JC, et al. Prevalence and risk factors of gallbladder polyps in health screening subjects. Korean J Med. 1999. 57:1014–1020.

7. Chen CY, Lu CL, Chang FY, Lee SD. Risk factors for gallbladder polyps in the Chinese population. Am J Gastroenterol. 1997. 92:2066–2068.

8. Renehan AG, Tyson M, Egger M, Heller RF, Zwahlen M. Body-mass index and incidence of cancer: a systematic review and meta-analysis of prospective observational studies. Lancet. 2008. 371:569–578.

9. Kuriyama S, Tsubono Y, Hozawa A, Shimazu T, Suzuki Y, Koizumi Y, Suzuki Y, Ohmori K, Nishino Y, Tsuji I. Obesity and risk of cancer in Japan. Int J Cancer. 2005. 113:148–157.

10. Larsson SC, Wolk A. Obesity and the risk of gallbladder cancer: a metaanalysis. Br J Cancer. 2007. 96:1457–1461.

11. Segawa K, Arisawa T, Niwa Y, Suzuki T, Tsukamoto Y, Goto H, Hamajima E, Shimodaira M, Ohmiya N. Prevalence of gallbladder polyps among apparently healthy Japanese: ultrasonographic study. Am J Gastroenterol. 1992. 87:630–633.

12. Kim SY, Lee HS, Lee YS, Chung KW, Jang BK, Chung WJ, Park KS, Cho KB, Hwang JS. Prevalence and risk factors of gallbladder polyp in adults living in Daegu and Gyeongbuk Provinces. Korean J Gastroenterol. 2006. 48:344–350.

13. Alberti KG, Zimmet P, Shaw J. IDF Epidemiology Task Force Consensus Group. The metabolic syndrome: a new worldwide definition. Lancet. 2005. 366:1059–1062.

14. Grundy SM, Cleeman JI, Daniels SR, Donato KA, Eckel RH, Franklin BA, Gordon DJ, Krauss RM, Savage PJ, Smith SC Jr, et al. Diagnosis and management of the metabolic syndrome: an American Heart Association/National Heart, Lung, and Blood Institute Scientific Statement. Circulation. 2005. 112:2735–2752.

15. Lee SY, Park HS, Kim DJ, Han JH, Kim SM, Cho GJ, Kim DY, Kwon HS, Kim SR, Lee CB, et al. Appropriate waist circumference cutoff points for central obesity in Korean adults. Diabetes Res Clin Pract. 2007. 75:72–80.

16. Jørgensen T, Jensen KH. Polyps in the gallbladder: a prevalence study. Scand J Gastroenterol. 1990. 25:281–286.

17. Shinchi K, Kono S, Honjo S, Imanishi K, Hirohata T. Epidemiology of gallbladder polyps: an ultrasonographic study of male self-defense officials in Japan. Scand J Gastroenterol. 1994. 29:7–10.

18. Collett JA, Allan RB, Chisholm RJ, Wilson IR, Burt MJ, Chapman BA. Gallbladder polyps: prospective study. J Ultrasound Med. 1998. 17:207–211.

19. Ozdemir A, Ozenc A, Bozoklu S, Cosķun T. Ultrasonography in the diagnosis of gallbladder polyps. Br J Surg. 1993. 80:345.

20. Kim J, Lee K. Relationship between metabolic syndrome and gallbladder stone. Korean J Fam Med. 2009. 30:610–616.

21. Lin WR, Lin DY, Tai DI, Hsieh SY, Lin CY, Sheen IS, Chiu CT. Prevalence of and risk factors for gallbladder polyps detected by ultrasonography among healthy Chinese: analysis of 34 669 cases. J Gastroenterol Hepatol. 2008. 23:965–969.

22. Hayashi Y, Liu JH, Moriguchi H, Takenawa H, Tazawa J, Nakayama E, Marumo F, Sato C. Prevalence of polypoid lesions of the gallbladder in urban and rural areas of Japan: comparison between 1988 and 1993. J Clin Gastroenterol. 1996. 23:158–159.

23. Salmenkivi K. Cholesterolosis of the gall-bladder: a clinical study based on 269 cholecystectomies. Acta Chir Scand. 1964. 105:1S–93S.

24. Tilvis RS, Aro J, Strandberg TE, Lempinen M, Miettinen TA. Lipid composition of bile and gallbladder mucosa in patients with acalculous cholesterolosis. Gastroenterology. 1982. 82:607–615.