J Korean Med Sci.  2012 Nov;27(11):1359-1363. 10.3346/jkms.2012.27.11.1359.

Determinants of Brachial-Ankle Pulse Wave Velocity in Normotensive Young Adults with Type 2 Diabetes Mellitus

• Choi BG
• Kang JH
• Jeon YK
• Kim SS
• Lee CW
• Kim IJ
• Kim YK
• Kim BH

• KMID: 2157947
• DOI: http://doi.org/10.3346/jkms.2012.27.11.1359

Abstract

Brachial-ankle pulse wave velocity (baPWV) is simple, noninvasive method which correlates well with arterial stiffness. Herein, we assessed the determinants of baPWV in normotensive young adults with type 2 diabetes. We retrospectively enrolled 103 consecutive type 2 diabetic patients aged between 30 and 39 yr who measured baPWV with noninvasive pulse wave analyzer. The anthropometric parameters, blood pressure, pulse rate, fasting plasma glucose, fasting insulin, fasting C-peptide, HbA1c, lipid profile, hs-CRP, albuminuria status, AST/ALT, gamma-GTP were checked concurrently. Also, we investigated history of smoking, alcohol drinking and medications by questionnaire. We found that maximal baPWV was positively correlated with mean blood pressure (r = 0.404, P < 0.001), heart rate (r = 0.285, P = 0.004), AST (r = 0.409, P < 0.001), ALT (r = 0.329, P = 0.001), gamma-GTP (r = 0.273, P = 0.006), Urine albumin/creatinine ratio (r = 0.321, P = 0.003). By multiple linear regression, mean blood pressure and heart rate were significantly associated with maximal baPWV in male and total group. In female group, mean blood pressure was the only variable associated with maximal baPWV. These factors can be surrogate markers of arterial stiffness in this population.

Keyword

Pulse Wave Velocity; Type 2 Diabetes; Normotension

MeSH Terms

Adult
Alanine Transaminase/blood
Ankle/*physiology
Aspartate Aminotransferases/blood
Blood Pressure/physiology
Brachial Artery/*physiology
C-Peptide/analysis
Diabetes Mellitus, Type 2/*physiopathology
Female
Heart Rate/physiology
Hemoglobin A, Glycosylated/analysis
Humans
Lipids/analysis
Male
Pulse Wave Analysis
Questionnaires
Retrospective Studies
Sex Factors
gamma-Glutamyltransferase/blood
C-Peptide
Hemoglobin A, Glycosylated
Lipids
gamma-Glutamyltransferase
Aspartate Aminotransferases
Alanine Transaminase

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