J Korean Med Sci.  2004 Aug;19(4):509-513. 10.3346/jkms.2004.19.4.509.

A Multi-center Study for Birth Defect Monitoring Systems in Korea

• Yang JH
• Kim YJ
• Chung JH
• Kim MY
• Ryu HM
• Ahn HK
• Han JY
• Yang SH
• Kim A
• Kim HS
• Lee PJ
• Kim SS
• Kim YJ
• Koh KS
• Shin JC
• Cho YK
• Yoon BH

• KMID: 2157677
• DOI: http://doi.org/10.3346/jkms.2004.19.4.509

Abstract

The aim of this study was to establish a multi-center birth defects monitoring system to evaluate the prevalence and the serial occurrence of birth defects in Korea. Ten medical centers participated in this program. A trained nurse collected relevant records from delivery units and pediatric clinics in participating hospitals on a monthly basis. We observed 1,537 cases of birth defects among 86,622 deliveries, which included live births and stillbirths. The prevalence of birth defects was 1.8%, and the sex distribution of the birth defect cases was 55.2% male and 41.6% female. The highest proportion of birth defects was in the cardiovascular system (17.5%), followed by birth defects involving in the genitourinary system (15.6%). Chromosomal anomalies were detected 30.0 per 10,000 births. Of these chromosomal anomalies, Down syndrome was most frequently observed. This study led to an establishment of a multi-center active monitoring system for birth defects. To better understand the serial occurrence of birth defects in Korea, it is necessary to increase the number of participating hospitals and to launch on a nation-wide multi-center study.

Keyword

Birth Defects; Abnormalities; Congenital abnormality; Multicenter Studies

MeSH Terms

Abnormalities/*epidemiology
Child
*Chromosome Aberrations
Female
Humans
Korea/epidemiology
Male
*Population Surveillance
Pregnancy
Pregnancy Outcome
Research Support, Non-U.S. Gov't

Reference

1. Liu S, Joseph KS, Wen SW. Trends in fetal and infant deaths caused by congenital anomalies. Semin Perinatol. 2002. 26:268–276.

2. Kalter H, Warkany J. Medical progress. Congenital malformations: etiologic factors and their role in prevention (first of two parts). N Engl J Med. 1983. 308:424–431.

3. Queisser-Luft A, Stolz G, Wiesel A, Schlaefer K, Spranger J. Malformations in newborn: results based on 30,940 infants and fetuses from the Mainz congenital birth defect monitoring system (1990-1998). Arch Gynecol Obstet. 2002. 266:163–167.

4. Lechat MF, Dolk H. Registries of congenital anomalies: EUROCAT. Environ Health Perspect. 1993. 101:Suppl 2. 153–157.

5. Kim YW, Kim SJ, Hur SY, Lee GS, Lee Y, Kim EJ, Song SK, Kim SP. The clinical study of congenital anomalies. Korean J Obstet Gynecol. 1998. 41:1698–1703.

6. Park HK, Lee CH, Nam KH, Lee KH, Cho TH. The clinical epidemiologic study of congenital anomalies in the newborn infants. Korean J Obstet Gynecol. 1993. 36:1383–1390.

7. Park HK, Nam KH, Lee KH, Cho TH. The clinical epidemiologic study of congenital anomalies in the newborn infants. Korean J Perinatol. 1991. 2:58–67.

8. International Clearinghouse for Birth Defects Monitoring Systems, Annual Report 1992. Rome: International Center for Birth Defects.

9. Metropolitan Atlanta Congenital Defect Program: Congenital malformations surveillance. 1988. Atlanta: Centers for Disease Control.

10. Epstein CJ. Rudolph AM, Hoffman JIE, Rudolph CD, editors. Genetic disorders and birth defects. Rudolph's pediatrics. 1991. 19th ed. Norwalk, CT: Appleton & Lange;265–269.

11. Shi LM, Chia SE, Chan OY, Chew SK, Foong BH. Prevalence of birth defects and parental work in Singapore live births from 1994 to 1998: a population-based study. Occup Med (Lond). 2002. 52:325–331.

12. WHO. ICD-9. International Classification of Diseases. 9th revision. Geneva: WHO.

13. WHO. ICD-10. International Classification of Diseases. 10th revision. Geneva: WHO.

14. BPA. Classification of Diseases. 1987. Vols 1&2:2nd ed. British Pediatric Association.

15. International Clearinghouse for Birth Defects Monitoring Systems, Annual Report 2000. Rome: International Center for Birth Defects.

16. Lindberg MC, Edmons LD. Halperin W, Baker EL, editors. Surveillance of birth defects. Public health surveillance. 1992. 12. New York: Van Nostrand Reinhold;157–177.

17. Iliyasu Z, Gilmour WH, Stone D. Prevalence of Down syndrome in Glasgow, 1980-96; the growing impact of prenatal diagnosis on younger mothers. Health Bull (Edinb). 2002. 60:20–26.

18. Taskinen HK. Effects of parental occupational exposures on spontaneous abortion and congenital malformation. Scand J Work Environ Health. 1990. 16:297–314.

19. Weber RF, Pierik FH, Dohle GR, Burdorf A. Environmental influences on male reproduction. BJU Int. 2002. 89:143–148.

20. Wells PG, Winn LM. Biochemical toxicology of chemical teratogenesis. Crit Rev Biochem Mol Biol. 1996. 31:1–40.

21. Solomon GM, Schettler T. Environment and health: 6. Endocrine disruption and potential human health implications. CMAJ. 2000. 163:1471–1476.

22. Wilson JG. Environmental and birth defects. 1973. New York: Academic Press.