Ann Dermatol.  2011 Sep;23(Suppl 1):S123-S126. 10.5021/ad.2011.23.S1.S123.

Application of Sentinel Lymph Node Biopsy in Cutaneous Basosquamous Carcinoma

• Jankovic I
• Kovacevic
• Visnjic M
• Jankovic D
• Binic I
• Jankovic A
• Ilic I

• KMID: 2156769
• DOI: http://doi.org/10.5021/ad.2011.23.S1.S123

Abstract

Basosquamous carcinoma of the skin is a relatively rare cutaneous neoplasm that has significant metastatic potential and a metastatic rate greater than that of basal cell and squamous cell carcinoma. We describe the use of lymphatic mapping and sentinel lymph node biopsy in a 63-year-old man after identification of basosquamous carcinoma. Sentinel lymph node biopsy, which is a standard tool to detect regional lymphatic metastasis in cutaneous melanoma, has been rarely employed to detect lymphatic metastasis of basosquamous carcinoma. The approach was successful in detecting a regional lymphatic metastasis of two nodal basins with minor morbidity. Sentinel lymph node biopsy may be useful for certain high-risk lesions of basosquamous carcinoma.

Keyword

Basosquamous carcinoma; Metastasis; Sentinel lymph node biopsy

MeSH Terms

Carcinoma, Basosquamous
Carcinoma, Squamous Cell
Humans
Lymphatic Metastasis
Melanoma
Middle Aged
Neoplasm Metastasis
Nitriles
Pyrethrins
Sentinel Lymph Node Biopsy
Skin
Nitriles
Pyrethrins

Figure

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  Fig. 1 Photograph of the lesion.

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  Fig. 2 Histopathological examination of the primary tumor. (A) Conventional basaloid tumor islands were admixed with more atypical tumor cells demonstrating higher grade cytologic atypia with squamous differentiation (H&E stain, ×200). (B) A high power view revealing BCC cells with squamous differentiation (H&E stain, ×400).

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  Fig. 3 SLN of the left axilla with metastatic BSC (CK AE1/AE3, ×10).

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  Fig. 4 SLN of the right axilla with isolated tumor cells of SCC(CK AE1/AE3, ×20).

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