Ann Dermatol.  2011 Sep;23(Suppl 1):S72-S74. 10.5021/ad.2011.23.S1.S72.

Development of Dermatomyofibroma in a Male Infant

• Sim JH
• Shin J
• Vandersteen DP
• Kim YC

• KMID: 2156756
• DOI: http://doi.org/10.5021/ad.2011.23.S1.S72

Abstract

Dermatomyofibroma is a rare benign cutaneous mesenchymal neoplasm of the fibroblasts and myofibroblasts. The majority of dermatomyofibromas present as red-brown discolored plaques or nodules, commonly located on the shoulder, upper arm, axilla, neck, and/or upper trunk. These lesions develop most frequently in young female patients at a mean of 28-years-of-age. Herein, a case of dermatomyofibroma is reported that developed in an infant. A 4-month-old boy presented with an ill-defined bluish firm plaque on the trunk that developed 1 month after birth. Histopathologically, there was proliferation of bland-looking spindle cells with fascicular arrangement in the dermis and subcutaneous tissue. Immunohistochemistry showed that most of the tumor cells expressed diffuse positivity for vimentin and smooth muscle actin, but were negative for S-100 protein, desmin, and CD34.

Keyword

Dermatomyofibroma; Infant

MeSH Terms

Actins
Arm
Axilla
Dermis
Desmin
Female
Fibroblasts
Humans
Immunohistochemistry
Infant
Male
Muscle, Smooth
Myofibroblasts
Neck
Parturition
S100 Proteins
Shoulder
Subcutaneous Tissue
Vimentin
Actins
Desmin
S100 Proteins
Vimentin

Figure

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  Fig. 1 An ill-defined bluish firm plaque on the left flank.

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  Fig. 2 Proliferation of bland-looking spindle cells with fascicular arrangement in the reticular dermis (A), extending focally into the subcutaneous tissue (B). There was no cytological atypia or mitotic figures (H&E; original magnification, A: ×40; B: ×200).

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  Fig. 3 Immunohistochemistry showed that most of the tumor cells expressed a diffuse positivity for smooth muscle actin (Original magnification, ×40).

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