Ann Dermatol.  2011 Sep;23(Suppl 1):S61-S63. 10.5021/ad.2011.23.S1.S61.

Non-familial Acrokeratosis Verruciformis of Hopf

• Bang CH
• Kim HS
• Park YM
• Kim HO
• Lee JY

• KMID: 2156753
• DOI: http://doi.org/10.5021/ad.2011.23.S1.S61

Abstract

Acrokeratosis verruciformis of Hopf is a rare genodermatosis with an autosomal dominant mode of inheritance. It is a disorder of keratinization, characterized by multiple, flat-topped, skin-colored keratotic lesions resembling plane warts typically observed on the dorsum of the hands and feet. Histopathologically, the lesion shows considerable hyperkeratosis, acanthosis, and papillomatosis, mimicking a "church spire", and a thickened granular layer. It arises in early life, often at birth or infancy. Herein, we report on a rare sporadic case of acrokeratosis verruciformis of Hopf. A 44-year-old Caucasian man presented with multiple, grouped, hyperkeratotic, whitish, flat papules on his shins and feet, which had been present for more than one year. Histopathological examination showed typical findings of acrokeratosis verruciformis of Hopf. Our case is unique in that the patient had no familial history of similar skin lesions.

Keyword

Acrokeratosis verruciformis of Hopf; Non-familial acrokeratosis verruciformis

MeSH Terms

Adult
Darier Disease
Foot
Hand
Humans
Keratins
Papilloma
Parturition
Skin
Warts
Wills
Keratins