Ann Dermatol.  2008 Sep;20(3):149-152. 10.5021/ad.2008.20.3.149.

Peripheral Neuropathy Associated withHypereosinophilic Syndrome

• Lee KH
• Kim JE
• Park CJ

• KMID: 2156383
• DOI: http://doi.org/10.5021/ad.2008.20.3.149

Abstract

The idiopathic hypereosinophilic syndrome (HES) represents a leukoproliferative disorder, characterized by unexplained prolonged eosinophilia (>6 months) and evidence of specific organ damage. So far, the peripheral neuropathy associated with skin manifestations of HES has not been reported in the dermatologic literature although the incidence of peripheral neuropathy after HES ranges from 6~52%. Herein, we report the peripheral neuropathy associated with HES, documented by clinical, histopathological, and electrodiagnostic criteria.

Keyword

Hypereosinophilic syndrome; Neuropathy

MeSH Terms

Eosinophilia
Hypereosinophilic Syndrome
Incidence
Peripheral Nervous System Diseases
Skin Manifestations

Figure

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  Fig. 1 (A) Multiple, indurated plaques and crusted papules on both edematous legs. (B) Extensive eosinophil infiltration in the dermis (H&E, original magnification, ×200).

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