Ann Dermatol.  2008 Sep;20(3):138-141. 10.5021/ad.2008.20.3.138.

A Case of Angiolymphoid Hyperplasia with Eosinophilia of the Lower Eyelid

• Lee JS
• Lee JB
• Kim SJ
• Lee SC
• Won YH
• Yun SJ

• KMID: 2156380
• DOI: http://doi.org/10.5021/ad.2008.20.3.138

Abstract

Angiolymphoid hyperplasia with eosinophilia (ALHE) is a subcutaneous angioproliferating tumor with a characteristic inflammatory infiltrate that consists mainly of lymphocytes and eosinophils. A 24-year-old man presented with a firm single asymptomatic erythematous papule on the lower eyelid. Histopathological findings showed a proliferation of blood vessels lined with epithelioid cells and perivascular infiltration of lymphocytes and eosinophils. We report a case of ALHE occurring on an unusual site.

Keyword

Angiolymphoid hyperplasia with eosinophilia; Lower eyelid

MeSH Terms

Angiolymphoid Hyperplasia with Eosinophilia
Blood Vessels
Eosinophils
Epithelioid Cells
Eyelids
Humans
Lymphocytes
Young Adult

Figure

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  Fig. 1 A single firm erythematous 5-mm sized, round papule on the right lower eyelid.

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  Fig. 2 Histopathologic examination reveals dense multiple lobular infiltrations of lymphocytes and eosinophils with central proliferation of vessels throughout the dermis (A: H&E, ×200). The endothelial cells have a hobnail appearance, protruding into the vascular lumen (B) and some endothelial cells have vacuoles in the cytoplasm (C) (B and C: H&E, ×400).

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