Ann Dermatol.  2008 Sep;20(3):138-141. 10.5021/ad.2008.20.3.138.

A Case of Angiolymphoid Hyperplasia with Eosinophilia of the Lower Eyelid

  • 1Department of Dermatology, Chonnam National University Medical School, Gwangju, Korea.


Angiolymphoid hyperplasia with eosinophilia (ALHE) is a subcutaneous angioproliferating tumor with a characteristic inflammatory infiltrate that consists mainly of lymphocytes and eosinophils. A 24-year-old man presented with a firm single asymptomatic erythematous papule on the lower eyelid. Histopathological findings showed a proliferation of blood vessels lined with epithelioid cells and perivascular infiltration of lymphocytes and eosinophils. We report a case of ALHE occurring on an unusual site.


Angiolymphoid hyperplasia with eosinophilia; Lower eyelid

MeSH Terms

Angiolymphoid Hyperplasia with Eosinophilia
Blood Vessels
Epithelioid Cells
Young Adult


  • Fig. 1 A single firm erythematous 5-mm sized, round papule on the right lower eyelid.

  • Fig. 2 Histopathologic examination reveals dense multiple lobular infiltrations of lymphocytes and eosinophils with central proliferation of vessels throughout the dermis (A: H&E, ×200). The endothelial cells have a hobnail appearance, protruding into the vascular lumen (B) and some endothelial cells have vacuoles in the cytoplasm (C) (B and C: H&E, ×400).

Cited by  1 articles

Angiolymphoid Hyperplasia with Eosinophilia on the Palm
Seong Min Kim, Jimi Yoon, Tae-Jin Yoon
Ann Dermatol. 2010;22(3):358-361.    doi: 10.5021/ad.2010.22.3.358.


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