Ann Rehabil Med.  2016 Feb;40(1):56-65. 10.5535/arm.2016.40.1.56.

Relationship of Vascular Factors on Electrophysiologic Severity of Diabetic Neuropathy

• Hwang JW
• Pyun SB
• Kwon HK

• KMID: 2155166
• DOI: http://doi.org/10.5535/arm.2016.40.1.56

Abstract

OBJECTIVE
To investigate the impact of vascular factors on the electrophysiologic severity of diabetic neuropathy (DPN).
METHODS
Total 530 patients with type 2 diabetes were enrolled retrospectively. We rated severity of DPN from 1 (normal) to 4 (severe) based on electrophysiologic findings. We collected the data concerning vascular factors (including brachial-ankle pulse wave velocity [PWV], ankle brachial index, ultrasound of carotid artery, lipid profile from the blood test, and microalbuminuria [MU] within 24 hours urine), and metabolic factors of diabetes (such as glycated hemoglobin [HbA1c]). We analyzed the differences among the four subgroups using χ2 test and ANOVA, and ordinal logistic regression analysis was performed to investigate the relationship between significant variables and severity of DPN.
RESULTS
The severity of DPN was significantly associated with duration of diabetes, HbA1c, existence of diabetic retinopathy and nephropathy, PWV, presence of plaque, low density lipoprotein-cholesterol and MU (p<0.05). Among these variables, HbA1c and presence of plaque were more significantly related with severity of DPN in logistic regression analysis (p<0.001), and presence of plaque showed the highest odds ratio (OR=2.52).
CONCLUSION
Our results suggest that markers for vascular wall properties, such as PWV and presence of plaque, are significantly associated with the severity of DPN. The presence of plaque was more strongly associated with the severity of DPN than other variables.

Keyword

Diabetic neuropathies; Electromyography; Diabetic angiopathies; Pulse wave analysis; Carotid stenosis

MeSH Terms

Ankle Brachial Index
Carotid Arteries
Carotid Stenosis
Diabetic Angiopathies
Diabetic Neuropathies*
Diabetic Retinopathy
Electromyography
Hematologic Tests
Hemoglobin A, Glycosylated
Humans
Logistic Models
Odds Ratio
Pulse Wave Analysis
Retrospective Studies
Ultrasonography

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