Osteoporosis.  2015 Dec;13(2):81-87. 10.0000/ost.2015.13.2.81.

Medication Persistence for Osteoporosis and Its Related Factor in Patients with Osteoporotic Compression Vertebral Fracture

• Kim SS
• Lim DJ
• Kim JH
• Kim SK
• Oh SY
• Suk SI

• KMID: 2155129
• DOI: http://doi.org/10.0000/ost.2015.13.2.81

Abstract

INTRODUCTION
Osteoporotic vertebral fractures, which account for the largest part of the disease has become important and common diseases. We studied persistence for osteoporosis medication and its related factor in patients with osteoporotic compression vertebral fracture.
METHODS
A total of 458 patients that visited our outpatient clinic with osteoporotic vertebral fractures and were prescribed with osteoporosis medication at the Seoul Spine Center from January 2010 to February 2014 and were analyzed retrospectively. The male to female ratio was 403: 55 and the mean age was 75 years. Survival analysis was used with the Kaplan-Meier method. Related factor analysis was performed with the log rank test and Cox regression test.
RESULTS
The survival rate at 6 months was 52%, 12 months was 40%, 24 months was 28%, and at 3 years it was 25%. There was no difference between the persistent rate according to age. Women demonstrated higher persistent rate than men in significantly. It showed a significant difference between some of the groups in accordance with the dose rate and duration of the drug dose interval. Especially, medication change group had significant higher persistence rate than not changing group.
CONCLUSIONS
Persistence rate of osteoporosis drugs, decreased rapidly with the passage of time. The patients with changing medication during follow-up had significantly higher persistence ratio than those without it. The persistence rate of osteoporosis medication could be increased through actively solving the problems of the patients, which are associated with taking medication.

Keyword

Osteoporosis compression vertebral fracture; Osteoporosis medication; Persistence; Osteoporosis

MeSH Terms

Ambulatory Care Facilities
Female
Follow-Up Studies
Humans
Male
Medication Adherence*
Osteoporosis*
Retrospective Studies
Seoul
Spine
Survival Rate