J Pathol Transl Med.  2015 Jul;49(4):351-353. 10.4132/jptm.2015.05.06.

Salivary Gland Hyalinizing Clear Cell Carcinoma

• Lin JC
• Liao JB
• Fu HT
• Chang TS
• Wang JS

• KMID: 2151148
• DOI: http://doi.org/10.4132/jptm.2015.05.06

Abstract

No abstract available.

MeSH Terms

Hyalin*
Salivary Glands*

Figure

• 

  Fig. 1. (A) Hyalinizing clear cell carcinoma (HCCC) showing cords and nests of tumor cells with perineural invasion. The tumor cells have a clear cytoplasm (B) and are embedded in a characteristic dual hyaline and fibrocellular stroma (C). (D) Almost all clear cells are positive for p63. (E) The tumor cells are negative for CD10 while the myofibroblastic spindle cells in the stroma are positive for CD10. (F, G) Tumor cells with clear cytoplasm contain abundant glycogen which is positive for periodic acid–Schiff and sensitive to diastase digestion. (H) Fluorescence in situ hybridization shows a break-apart signal pattern in 25% of the tumor cells confirming the presence of EWSR1 rearrangement.

Reference

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