J Korean Ophthalmol Soc.  2015 Jul;56(7):1096-1103. 10.3341/jkos.2015.56.7.1096.

The Effect of Caffeinated Energy Drink Consumption on Intraocular Pressure in Young Adults

  • 1Department of Ophthalmology, Maryknoll Medical Center, Busan, Korea. Coolguy-2@daum.net


Several energy drinks containing a high content of caffeine are widely consumed among young adults. We examined the effects of caffeinated energy drinks on intraocular pressure (IOP) and blood pressure (BP) in healthy young subjects.
In this prospective randomized, case-controlled cross over study conducted, from August to September of 2014, 40 healthy young volunteers (80 eyes) in their 20's and 30's drank 2 types of beverage each consumed after a 3-month washout period. The study participants were randomly given the caffeinated energy drink (group I, n = 20) or caffeine-free drink (group II, n = 20), IOP and BP were measured at 0, 30, 60, 90, and 120 minutes and 12 and 24 hours after beverage consumption.
In group I, the mean +/- standard deviation (SD) of IOP at baseline was 13.2 +/- 1.56 mm Hg and the IOP increased until 24 hours after drink consumption. IOPs at 30, 60, 90, and 120 minutes and 12 and 24 hours after drinking caffeinated energy drink were 14.45 +/- 2.12, 14.93 +/- 2.02, 14.85 +/- 1.55, 14.2 +/- 1.34, 14.25 +/- 1.74, and 13.35 +/- 1.61, respectively and statistically significant at 30, 60, 90, 120 minutes and 12 hours (p < 0.05). A corresponding increase in BP after drinking the caffeinated energy drink was observed but without statistical significance. Drinking the caffeine-free beverage did not affect IOP or BP significantly.
IOP increases after consuming the caffeinated energy drink were statistically significant at 30, 60, 90, and 120 minutes and 12 hours. Therefore, caffeinated energy drinks may not be recommended for glaucoma patients or glaucoma suspects.


Caffeinated drink; Caffeine; Energy drink; Intraocular pressure

MeSH Terms

Blood Pressure
Case-Control Studies
Energy Drinks*
Intraocular Pressure*
Prospective Studies
Young Adult*


  • Figure 1. Study design. A prospective randomized, case-controlled crossover study.

  • Figure 2. (A) Intraocular pressure (IOP) measured by Goldmann applanation tonometer of caffeine free drink group and caffeinated energy drink group. (B) IOP measured by ocular response analyzer of caffeine free drink group and caffeinated energy drink group. IOP GAT = IOP measurement of a Goldmann applanation tonometer; IOP ORA = IOP measurement of an ocular response analyzer.* Bonferroni p-value, p < 0.05.

  • Figure 3. (A) Systolic blood pressure of caffeine free drink group and caffeinated energy drink group. (B) Diastolic blood pressure of caffeine free drink group and caffeinated energy drink group. BP = blood pressure. * Bonferroni p-value, p < 0.05.

Cited by  1 articles

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So Hyun Park, Seon Hwa Lee, Kyung Ja Chang
J Nutr Health. 2017;50(5):460-471.    doi: 10.4163/jnh.2017.50.5.460.



1. Rang HP, Dale MM, Ritter JM. Pharmacology. 3rd. Edinburgh: Churchill Livingstone;1995. p. 283–7.
2. Whitsett TL, Manion CV, Christensen HD. Cardiovascular effects of coffee and caffeine. Am J Cardiol. 1984; 53:918–22.
3. Smits P, Thien T, Van’t Laar A. The cardiovascular effects of regu-lar and decaffeinated coffee. Br J Clin Pharmacol. 1985; 19:852–4.
4. Sung BH, Whitsett TL, Lovallo WR, et al. Prolonged increase in blood pressure by a single dose of caffeine in mildly hypertensive man. Am J Hypertens. 1994; 7:755–8.
5. Mathew RJ, Wilson WH. Caffeine induced changes in cerebral circulation. Stroke. 1985; 16:814–7.
6. Adams BA, Brubaker RF. Caffeine has no clinically significant effect on aqueous humor flow in the normal human eye. Ophthalmology. 1990; 97:1030–1.
7. Chandra P, Gaur A, Varma S. Effect of caffeine on the intraocular pressure in patients with primary open angle glaucoma. Clin Ophthalmol. 2011; 5:1623–9.
8. Avisar R, Avisar E, Weinberger D. Effect of coffee consumption on intraocular pressure. Ann Pharmacother. 2002; 36:992–5.
9. Chandrasekaran S, Rochtchina E, Mitchell P. Effects of caffeine on intraocular pressure: the Blue Mountains Eye Study. J Glaucoma. 2005; 14:504–7.
10. Kang JH, Willett WC, Rosner BA, et al. Caffeine consumption and the risk of primary open angle glaucoma: a prospective cohort study. Invest Ophthalmol Vis Sci. 2008; 49:1924–31.
11. Ajayi OB, Ukwade MT. Caffeine and intraocular pressure in a Nigerian population. J Glaucoma. 2001; 10:25–31.
12. Benowitz NL. Clinical pharmacology of caffeine. Annu Rev Med. 1990; 41:277–88.
13. Laurence DR, Bennett PN. Clinical phamacology. 7th. Edinburgh: Churchill Livingstone;1994. p. 291–5.
14. Cavalcante JW, Santos PR Jr, Menezes MG, et al. Influence of caf-feine on blood pressure and platelet aggregation. Arq Bras Cardiol. 2000; 75:97–105.
15. Hartley TR, Sung BH, Pincomb GA, et al. Hypertension risk status and effect of caffeine on blood pressure. Hypertension. 2000; 36:137–41.
16. Onrot J, Goldeberg MR, Biaggioni I, et al. Hemodynamic and hu-moral effects of caffeine in autonomic failures. Therapeutic im-plications for postprandial hypotension. N Engl J Med. 1985; 313:549–54.
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