Cancer Res Treat.  2015 Jul;47(3):539-543. 10.4143/crt.2013.245.

Diffuse Large B-Cell Lymphoma with Involvement of the Breast and Testis in a Male Patient

• Choi E
• Jo JC
• Yoon DH
• Kim S
• Lee K
• Huh J
• Park CS
• Lee SW
• Suh C

• KMID: 2148506
• DOI: http://doi.org/10.4143/crt.2013.245

Abstract

Here we report a case of a 76-year-old man with diffuse large B-cell lymphoma (DLBCL) with simultaneous involvement of the right breast and left testicle. The patient underwent complete resection of the involved testis, followed by immunochemotherapy with rituximab, cyclophosphamide, doxorubicin, vincristine, and prednisolone (R-CHOP) and prophylactic radiotherapy to the contralateral testis. Following this multimodal therapy, he achieved a complete response. This is a rare case of DLBCL involving both the breast and the testis in a male patient.

Keyword

Diffuse large B-cell lymphoma; Breast; Testis; Male

MeSH Terms

Aged
Breast*
Cyclophosphamide
Doxorubicin
Humans
Lymphoma, B-Cell*
Male
Prednisolone
Radiotherapy
Testis*
Vincristine
Cyclophosphamide
Doxorubicin
Prednisolone
Vincristine

Figure

• 

  Fig. 1. (A) Hematoxylin and eosin (H&E)–stained image showing diffuse large B-cell lymphoma of the right breast. (B) Immunohistochemical staining with positivity for CD20. (C) Gross specimen of the right testis, epididymis, and spermatic cord with an ovoid mass (3.8×2.5×1.6 cm). (D) H&E-stained image consistent with diffuse large B-cell lymphoma of the testis.

• 

  Fig. 2. A-C) Positron emission tomography–computed tomography (PET-CT) showing hypermetabolism in the right breast and right testis. (D) PET-CT after four cycles of rituximab, cyclophosphamide, doxorubicin, vincristine, and prednisolone (R-CHOP), showing a complete response.

Reference

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