Korean J Dermatol.  1984 Jun;22(3):280-285.

Congenital Syphilis: Outcomes of Offsprings from Untreated and Treated Syphilitic Mothers and Clinical Manifestations of Early Congenital Syphilis

• Lee JB
• Kim DK
• Cho CK
• Lee SN

Abstract

A retrospective study was made of the medical records of 114 pregnant women with untreated syphilis and their offsprings, and 19 pregnant women with treated syphilis and their offsprings at Severance Hospital, Yonsei University College of Medicine during the years 1972 through 1981. We analyzed the outcornes of offsprings from both untreated and treated syphilitic mothers and the clinical manife- stations of early congenital syphilis. The results obtained were as follows: Of 30 offsprings from 30 untreated syphilitic mothers with VDRL titer below 1: 4, six(20%) had congenital syphilis, one(3%) was a stillbirth, and twenty-three were normal infants. Of 84 offsprings from 84 untreated syphilitic mothers with VDRL titer above 1: 8, fifty-six(67g) had congenital syphilis, ten(12g,) were neonatal deaths, and eighteen(21%) were stillbirths, Normal infants were not observed. The mean weight ratio of placenta to fetus was 0 29 in g8 offsprings from syphilitic mothers. The ratios were as follows: 0. 25 in 14 living infants with con- genital syphilis, 0. 27 in 5 neonatal deaths, and (), 33 in 19 stillbirths respectively. 3, Of 19 pregnant women with treated syphilis, the qualitative tests of VDRL were all reactive except for one case and the quantitatis e tests of VDRL were 1: 1 weakly reactive to 1: 4 reactive. FTA-ABS tests demonstrated reactive results in all cases. The qualitative tests of VDRL in the infeants of the treated mothers were 1: 1 weakly reactive to 1: 2 reactive and FTA-ABS tests were reactive in all cases.-countinue-

MeSH Terms

Female
Fetus
Fluorescent Treponemal Antibody-Absorption Test
Humans
Infant
Medical Records
Mothers*
Placenta
Pregnant Women
Retrospective Studies
Stillbirth
Syphilis
Syphilis, Congenital*