Korean Circ J.  1986 Mar;16(1):95-102. 10.4070/kcj.1986.16.1.95.

A Study on the Relationship of the Frequency of Cardiac Arrhythmia, Plasma Catecholamine and Serum Cardiac Enzyme in Acute Stroke

• Kim BH
• Lee JW
• Kim KS
• Kim MS
• Bae JH
• Song JS

• KMID: 2145752
• DOI: http://doi.org/10.4070/kcj.1986.16.1.95

Abstract

Acute stroke has been associated with a variety of cardiac abnormalities. Data derived from EGC monitoring have suggested that cardiac arrhythmia may be more common in stroke patient. Acute stroke such as cerebral infarction has been reported to increase serum cardiac enzyme and histologic changes, focal myocardial myocytolysis. Also, plasma norepinephrine was significantly elevated in a group of stroke patients compared with non-stroke control. These observations led to the hypothesis that acute stroke may increase sympathetic activity with resultant electrocardiographic abnormalities and myocardial cell necrosis. In order to test this hypothesis, we evaluated 24 acute stroke patients for several cardiac parameter including arrythmias defected by 24 hour Holter monitoring, serum cardiac enzymes such as CK, LDH, SGOT and plasma catecholamine values. Similar studies were also performed in 15 control subjects matched with stroke patients for age. The result were as follows; 1) Arrhythmias such as VPB, SVPB in the acute stroke group were more common than in the non-stroke group. VPB(209+/-61/24hr, P<0.005) SVPB(232+/-54/24hr, P<0.005). 2) Plasma norepinephrine, epinephrine and CK was significantly elevated in a group of stroke patients compared with non-stroke controls. norepinephrine(715.3+/-93.8 pg/ml, P<0.005) epinephrine(346.1+/-63.1 pg/ml, P<0.005). 3) Stroke patients with abnormal serum CK values(above 80 IU/L) had a higher(P<0.05) mean norepinephrine concentration(776.6+/-142.0 pg/ml) than remaining stroke patients(406.3+/-101.7 pg/ml). 4) Stroke patients with high plasma norepinephrine did not exhibit an increase in cardiac arrhythmias.

MeSH Terms

Arrhythmias, Cardiac*
Aspartate Aminotransferases
Cerebral Infarction
Electrocardiography
Electrocardiography, Ambulatory
Epinephrine
Humans
Necrosis
Norepinephrine
Plasma*
Stroke*
Aspartate Aminotransferases
Epinephrine
Norepinephrine