J Korean Surg Soc.  2012 Nov;83(5):330-334. 10.4174/jkss.2012.83.5.330.

Pancreatic hamartoma diagnosed after surgical resection

• Kim HH
• Cho CK
• Hur YH
• Koh YS
• Kim JC
• Kim HJ
• Kim JW
• Kim Y
• Lee JH

• KMID: 2145012
• DOI: http://doi.org/10.4174/jkss.2012.83.5.330

Abstract

A pancreatic hamartoma is a rare benign lesion that may be mistaken for malignancy. A pancreatic hamartoma can present with vague, non-specific symptoms, which can be difficult to diagnose despite modern diagnostic tools. We report here a pancreatic hamartoma diagnosed after surgical resection. A 52-year-old female presented with postprandial abdominal discomfort. Abdominal computed tomography and pancreatic magnetic resonance imaging revealed a 2.2 x 2.5-cm cystic mass in the pancreatic head. The patient underwent a pylorus-preserving pancreaticoduodenectomy. The histopathological and immunohistochemical studies helped make the diagnosis of pancreatic hamartoma. Here, we report a case of pancreatic hamartoma and review the relevant medical literature.

Keyword

Hamartoma; Pancreas; Pancreaticoduodenectomy

MeSH Terms

Female
Hamartoma
Head
Humans
Magnetic Resonance Imaging
Middle Aged
Pancreas
Pancreaticoduodenectomy

Figure

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  Fig. 1 (A) Abdominal computed tomography demonstrated a 2-cm nodule in the head of the pancreas. (B) The gallbladder wall was thickened and enhanced after administering intravenous contrast medium.

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  Fig. 2 (A-C) Pancreatic magnetic resonance imaging showed a 2.2-cm, relatively well-defined, nodular mass in the pancreatic head. (D) There was a 1.4-cm cystic or necrotic portion with septation in the superomedial aspect of the mass.

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  Fig. 3 (A) Gross and microscopic findings of pancreatic hamartoma. The cut surface of the tumor was whitish and showed signs of focal necrosis with cystic change. Histologically, the tumor was composed of haphazardly distributed, cystic ductal elements lined by cuboidal to flattened epithelium, surrounded by well-differentiated acini embedded in fibro-inflammatory stroma (B: H&E, ×20; C: H&E, ×200). The immunohistochemical findings showed positive staining for CD34 (D, ×100) and positive/negative staining for c-kit (E, ×100).

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