Korean J Med.  2010 Feb;78(2):207-214.

Factors determining renal function in Korean patients with autosomal dominant polycystic kidney disease

Affiliations
  • 1Department of Internal Medicine, Pusan National University School of Medicine, Busan, Korea. iskwak@pusan.ac.kr

Abstract

BACKGROUND/AIMS: Previous studies of autosomal dominant polycystic kidney disease (ADPKD) in Koreans have been predominantly cross-sectional and insufficient to elucidate factors determining renal function.
METHODS
We retrospectively reviewed the medical records of 60 patients who were diagnosed with ADPKD in our hospital from 1995 to 2005. We surveyed the basal characteristics, symptoms, signs, blood and urine laboratory findings, radiologic extrarenal abnormalities, and kidney length through ultrasonography, and these measures were analyzed to identify their relationship to decreased renal function.
RESULTS
The clinical characteristics, such as symptoms and signs, were similar to those reported previously. Following t-tests and simple regression analyses, the statistically significant variables related to renal function deterioration were as follows: hypertension (with decreased renal function, 2.5 mL/min/1.73 m2/year more rapidly than the no-hypertension group, p=0.006), hypercholesterolemia (p=0.007), hypernatremia (p=0.011), mean kidney length (beta=0.378, p=0.029), and albumin (beta=-2.067, p=0.003). The multiple regression analysis revealed that the significant factors were hypertension (beta=0.261, p=0.016), mean kidney length (beta =0.211, p=0.047), and hypernatremia (beta=0.244, p=0.024).
CONCLUSIONS
The independent risk factors for deteriorating renal function in Korean patients with ADPKD were hypertension, hypernatremia, and mean kidney length.

Keyword

ADPKD; Kidney failure

MeSH Terms

Humans
Hypercholesterolemia
Hypernatremia
Hypertension
Kidney
Medical Records
Polycystic Kidney, Autosomal Dominant
Renal Insufficiency
Retrospective Studies
Risk Factors
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