Korean J Obstet Gynecol.
2006 May;49(5):1065-1072.
Increased expressions of claudin-1 and claudin-7 in cervical squamous intraepithelial neoplasias and invasive squamous cell carcinomas
- Affiliations
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- 1Department of Obstetrics and Gynecology, College of Medicine, Inha University, Incheon, Korea. songsong2000@inha.ac.kr
- 2Department of Pathology, College of Medicine, Inha University, Incheon, Korea.
- 3Department of General Surgery, College of Medicine, Inha University, Incheon, Korea.
- 4Inha Research Institute for Medical Science, Inha University, Incheon, Korea.
Abstract
OBJECTIVE
The change of claudin expressions, integral transmembrane proteins for tight junction, might be related to progression of cervical premalignancy or malignancy. The aim of this study was to verify the tendency of expressions of claudin-1 and -7 according to the progression of cervical pathology of uterus.
METHODS
There were 162 tissues obtained at AA institute. 25 tissues were normal, 26 were cervical intraepithelial neoplasia (CIN) 1, 30 were CIN2, 44 were CIN3, 25 were microinvasive cervical carcinomas, and 12 were invasive squamous cervical carcinomas (ISCC). H and E and immunohistochemical staining were done.
RESULTS
Among normal tissues, 52% showed no expression, 48% weak expressions at claudin-1, and 28% no expression, 56% weak expressions at claudin-7. Among CIN3, 20% showed weak expressions, 41% showed moderate expressions at claudin-1, and 14% weak expressions, 52% moderate expressions at claudin-7. Among ISCC, 42% showed moderate expressions, 50% strong expressions at claudin-1, and 33% moderate expressions, and 33% strong expressions at claudin-7. These data shows the increasing tendency of claudin-1 and claudin-7 expressions according to the severity of lesions (p<0.01).
CONCLUSION
The expressions of claudin-1 and claudin-7 were increased more according to the progression of cervical lesions.
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