Korean J Otorhinolaryngol-Head Neck Surg.  2015 Aug;58(8):534-539. 10.3342/kjorl-hns.2015.58.8.534.

Radioactive Iodine-Induced Sialadenitis

• Nam IC

• KMID: 2141113
• DOI: http://doi.org/10.3342/kjorl-hns.2015.58.8.534

Abstract

Radioactive iodine (131I) targets the thyroid gland and has been proven to play an effective role in the treatment of differentiated thyroid cancers. However, this radioisotope is simultaneously absorbed on the salivary glands where it is concentrated and secreted into the saliva. Dose related damage to the salivary parenchyma results from the 131I irradiation. Salivary gland swelling and pain, usually involving the parotid, can be seen. The symptoms may develop immediately after a therapeutic dose of 131I and/or months later and progress in intensity with time. Prevention of the 131I-induced sialadenitis includes the use of sialagogic agents to enhance the transit time of the 131I through the salivary glands. However, many studies are not available to delineate the efficacy of this approach. Recently, amifostine has been advocated to prevent the effects of irradiation. Treatment of the varied complications that may develop encompass numerous approaches and include gland massage, sialagogic agents, duct probing, antibiotics, mouthwashes, good oral hygiene, and adequate hydration.

Keyword

Iodine; Radioactivity; Sialadenitis

MeSH Terms

Amifostine
Anti-Bacterial Agents
Iodine
Massage
Mouthwashes
Oral Hygiene
Radioactivity
Saliva
Salivary Glands
Sialadenitis*
Thyroid Gland
Amifostine
Anti-Bacterial Agents
Iodine
Mouthwashes