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The Combined Effects of Amifostine and Interleukin 1 Beta (IL-1beta) on Radiation-induced Gastrointestinal and Hematopoietic Injury

Jang SS, Park WY

  • KMID: 1972875
  • Cancer Res Treat.
  • 2003 Dec;35(6):528-532.
PURPOSE: The pattern of radioprotection by the combined use of low dose amifostine plus IL-1beta was investigated in mice exposed to an acute whole-body radiation dose of 10 Gy. MATERIALS...
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Amifostine Pretreatment for Protection against Cisplatin-based Combination Chemotherapy in Gynecologic Cancer Patients

Lee LH, Jee HJ, Jung HK, Jung Y, Shin JH, Oh HS, Park YK, Hur JY, Chough SY, Saw HS

  • KMID: 2076393
  • Korean J Obstet Gynecol.
  • 2001 Nov;44(11):1961-1967.
OBJECTIVE: Amifostine (Ethyol(R)), an organic thiophosphate, has shown the ability to protect normal, but not neoplastic, tissues from the damaging effects of chemotherapy and radiotherapy in various kinds of cancers....
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Ex vivo Expansion of Hematopoietic Cells and Amifostine Effects

Ryoo HM, Bae SH, Hyun MS

  • KMID: 1637339
  • Korean J Hematol.
  • 2004 Sep;39(3):158-166.
BACKGROUND: The possibility of cord blood transplantation in adults was limited by the amount of cord blood that could be collected. Cord blood transplantation after ex vivo expansion with cytokines...
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Amifostine ameliorates recognition memory defect in acute radiation syndrome caused by relatively low-dose of gamma radiation

Lee HJ, Kim JS, Song MS, Seo HS, Yang M, Kim JC, Jo SK, Shin T, Moon C, Kim SH

This study examined whether amifostine (WR-2721) could attenuate memory impairment and suppress hippocampal neurogenesis in adult mice with the relatively low-dose exposure of acute radiation syndrome (ARS). These were assessed...
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Cardioprotective Potency of the Antioxidante Amifostine in the Ischemic and Reperfused Isolated Rat Heart

Huh GB, Chun SB

  • KMID: 1987819
  • Korean J Thorac Cardiovasc Surg.
  • 1998 Sep;31(9):845-854.
BACKGROUND: S-2-(3 aminoprophlamino) ethylphosphorothioic acid (WR-2721) is one of the radical scavenging thiols. We tested its protective effects in the reperfused heart. MATERIAL AND METHOD: The experimental setup was the...
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Radioprotective Effect of Epigallocatechin-3-Gallate on Salivary Gland Dysfunction After Radioiodine Ablation in a Murine Model

Choi JS, An HY, Park IS, Kim SK, Kim YM, Lim JY

OBJECTIVES: Radioiodine (RI) therapy is known to subject cellular components of salivary glands (SG) to oxidative stress leading to SG dysfunction. However, the protective effects of antioxidants on RI-induced SG...
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Radioactive Iodine-Induced Sialadenitis

Nam IC

Radioactive iodine (131I) targets the thyroid gland and has been proven to play an effective role in the treatment of differentiated thyroid cancers. However, this radioisotope is simultaneously absorbed on...
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Natural radioprotectors and their impact on cancer drug discovery

Kuruba V, Gollapalli P

Cancer is a complex multifaceted illness that affects different patients in discrete ways. For a number of cancers the use of chemotherapy has become standard practice. Chemotherapy is a use...
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Cytotoxicity of gamma-ray in rat immature hippocampal neurons

Yang M, Song MS, Kim SH, Kim JC, Kim JS, Shin T, Moon C

This in vitro study evaluated the detrimental effect of acute gamma (gamma)-irradiation on rat immature hippocampal neurons. Rat immature hippocampal neurons (0.5 day in vitro) were irradiated with 0~4 Gy...
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