Korean J Pediatr.  2007 Sep;50(9):901-904. 10.3345/kjp.2007.50.9.901.

Clinical and Radiological Analysis of Reversible Posterior Leukoencephalopathy Syndrome in Children

• Lim HR
• Seo HE
• Kwon SH

• KMID: 2140821
• DOI: http://doi.org/10.3345/kjp.2007.50.9.901

Abstract

clinical and radiologic findings that mainly involve the white/gray matter of the parieto-occipital lobes. The purpose of this study was to determine its clinical and radiological characteristics.
METHODS
A total of 15 pateints were involved in the study. Their medical records and radiological features of brain MRI were retrospectively reviewed and analyzed.
RESULTS
Fifteen pateints were involved. (9 males and 5 females). The patients' ages ranged from 2-20 years (mean age:10 years). The brain MRI revealed fairly symmetric areas of increased T2 signal involving both white and gray matter of parieto-occipital regions. The condition seemed to be associated with cyclosporin A and steroid therapy or a variety of other conditions in which blood pressure rises acutely.
CONCLUSION
Reversible posterior leukoencephalopathy syndrome is a complicated neurological condition, but a better understanding of this complex syndrome may obviate unnecessary investigations and lead to prompt and appropriate management of the associated problems.

Keyword

Leukoencephalopathy; Seizure; Cyclosporin; Steroid

MeSH Terms

Blood Pressure
Brain
Child*
Cyclosporine
Humans
Leukoencephalopathies
Magnetic Resonance Imaging
Male
Medical Records
Posterior Leukoencephalopathy Syndrome*
Retrospective Studies
Seizures
Cyclosporine