Korean J Thorac Cardiovasc Surg.  2006 Oct;39(10):770-774.

The Effects of Diluted Fibrin Glue about Continuous Air Leakage after Lung Surgery

Affiliations
  • 1Department of Thoracic and Cardiovascular Surgery, Soonchunhyang University College of Medicine, korea. csdoctor@sch.ac.kr

Abstract

BACKGROUNG: Continuous air leakage through chest tube after lung surgery may increase pt's hospital stay and lead to many complications including empyema etc. Chemical pleurodesis has frequently been used for prevention of air leakage. Therefore, we performed chemical pleurodesis using diluted fibrin glue in patients with continuous air leakage and observed the effects and efficiency of treatment. MATERIAL AND METHOD: From September, 2001 to August, 2005, 16 patients whose continuous air leakage lasted more than 7 days underwent chemical pleurodesis with diluted fibrin glue. The effects of treatment, complications and recurrences were reviewed. Dissolved fibrinogen 1.0 g and aprotinin 500,000 KIU were mixed in a 50 cc syringe (Mixed solution A). And dissolved thrombin 5,000 IU and Calcium chloride 600 mg were mixed in a 50 cc syringe (Mixed solution B). Cefazolin 1.0 g was mixed in a 50 cc syringe (Mixed solution C). Rubber tube was inserted between the chest tube and the collecting bottle. An inserted rubber tube was positioned 60cm above the patient and forming a loop appearance was done. Mixed solutions A, B and C were injected into the highest rubber tube.
RESULTS
Continuous air leakages disappeared in all 16 patients at next day. Chest tubes were removed after 3 days in all patients. Complications were chest pain in 12 patients (75%), leukocytosis in 14 patients (88%), fever and chill in 14 patients (88%). All complicaitons were transient and disappeared without specific treatment.
CONCLUSION
Our findings demonstrated that diluted fibrin glue chemical pleurodesis was effective in patients with continuous air leakage lasting more than 7 days. Diluted fibrin glue chemical pleurodesis had good results with acceptable complications. Long term follow-up is necessary to evaluate the accurate effects of treatment and recurrence in a large number of patients.

Keyword

Lung surgery; Air leakage; Pleurodesis; Tissue adhesives; Fibrin tissue adhesives

MeSH Terms

Aprotinin
Calcium Chloride
Cefazolin
Chest Pain
Chest Tubes
Empyema
Fever
Fibrin Tissue Adhesive*
Fibrin*
Fibrinogen
Humans
Length of Stay
Leukocytosis
Lung*
Pleurodesis
Recurrence
Rubber
Syringes
Thrombin
Tissue Adhesives
Aprotinin
Calcium Chloride
Cefazolin
Fibrin
Fibrin Tissue Adhesive
Fibrinogen
Rubber
Thrombin
Tissue Adhesives
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