Korean J Urol.  2007 Oct;48(10):1092-1095. 10.4111/kju.2007.48.10.1092.

Adenocarcinoma of the Prostate Gland Accompanied by Primary Small Cell Carcinoma of the Bladder

• Choi MH
• Bak JW
• Lee SH
• Lee HS
• Sim WS
• Park HK
• Yoon SJ

• KMID: 2139745
• DOI: http://doi.org/10.4111/kju.2007.48.10.1092

Abstract

Small cell carcinoma in the urinary bladder is very rare. There are only a handful of cases reported in the medical literature to date. A case of a primary bladder small cell carcinoma, detected by magnetic resonance imaging(MRI) during a follow up examination of a 77-year-old male patient who visited the outpatient clinic of our institution initially complaining of voiding difficulties and diagnosed with adenocarcinoma of the prostate gland with a Gleason score of 10 is, herein, reported. (Korean J Urol 2007;48:1092-1095)

Keyword

Small cell carcinoma; Urinary bladder; Adenocarcinoma; Prostate gland

MeSH Terms

Adenocarcinoma*
Aged
Ambulatory Care Facilities
Carcinoma, Small Cell*
Follow-Up Studies
Hand
Humans
Male
Neoplasm Grading
Prostate*
Urinary Bladder*

Figure

• 

  Fig. 1 An image of the transrectal ultrasonography (TRUS) of the prostate gland and result of the TRUS-guided needle biopsy of the prostate gland. (A) A hypoechoic lesion in the peripheral zone is noted (arrow). (B) Adenocarcinoma of the prostate gland (Hematoxylin-Eosin (HE) stain, ×100).

• 

  Fig. 2 Images of the prostate gland by magnetic resonance imaging (MRI). Diffuse low signal intensity at both peripheral zones from apex to base and both seminal vesicles in the T2 weighted image.

• 

  Fig. 3 Immunohistochemical staining confirmed the neuroendocrine activity of the small cell carcinoma and showed that the tumor cells were positive for CD56, weakly positive for synaptophysin, while negative for cytokeratin, chromogranin, leukocyte common antigen (LCA), T-cell (UCHL-1), CD3, CD20, and prostate-specific antigen (PSA) (HE stain, ×400).

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