Nutr Res Pract.  2008 Dec;2(4):326-330. 10.4162/nrp.2008.2.4.326.

Isomer specificity of conjugated linoleic acid (CLA): 9E,11E-CLA

Affiliations
  • 1Obesity and metabolism laboratory, Jean Mayer USDA HNRCA at Tufts University, Boston, MA 02111, USA. Yunkyoung.lee@tufts.edu

Abstract

Conjugated linoleic acids (CLA) were identified in 1980's, since then it has been intensively studied due to its various beneficial health effects such as anti-inflammatory, anti-atherogenic, anti-carcinogenic and anti-diabetic/obesity effects. Isomer specificity of a number of CLA isomers, especially predominant isomer 9Z,11E- and 10E,12Z-CLA, is now recognized. However, the less prevalent CLA isomers have not been well characterized. Recently, studies have reported the distinctively different effects of 9E,11E-CLA in colon cancer cells, endothelial cells, and macrophage cells compared to the rest of CLA isomers. In this review, various effects of CLAs, especially anti-inflammatory and anti-atherogenic effects, will be discussed with focusing on the isomer-specific effects and potential mechanism of action of CLA. At last, recent studies about 9E,11E-CLA in in vitro and animal models will be discussed.

Keyword

Conjugated linoleic acid (CLA); 9E,11E-CLA; anti-inflammatory; isomer-specificity

MeSH Terms

Colonic Neoplasms
Endothelial Cells
Linoleic Acid
Linoleic Acids, Conjugated
Macrophages
Models, Animal
Sensitivity and Specificity*
Linoleic Acid
Linoleic Acids, Conjugated
Full Text Links
  • NRP
Actions
Cited
CITED
export Copy
Close
Share
  • Twitter
  • Facebook
Similar articles
Copyright © 2022 by Korean Association of Medical Journal Editors. All rights reserved.     E-mail: koreamed@kamje.or.kr