Nutr Res Pract.  2008 Dec;2(4):326-330. 10.4162/nrp.2008.2.4.326.

Isomer specificity of conjugated linoleic acid (CLA): 9E,11E-CLA

  • 1Obesity and metabolism laboratory, Jean Mayer USDA HNRCA at Tufts University, Boston, MA 02111, USA.


Conjugated linoleic acids (CLA) were identified in 1980's, since then it has been intensively studied due to its various beneficial health effects such as anti-inflammatory, anti-atherogenic, anti-carcinogenic and anti-diabetic/obesity effects. Isomer specificity of a number of CLA isomers, especially predominant isomer 9Z,11E- and 10E,12Z-CLA, is now recognized. However, the less prevalent CLA isomers have not been well characterized. Recently, studies have reported the distinctively different effects of 9E,11E-CLA in colon cancer cells, endothelial cells, and macrophage cells compared to the rest of CLA isomers. In this review, various effects of CLAs, especially anti-inflammatory and anti-atherogenic effects, will be discussed with focusing on the isomer-specific effects and potential mechanism of action of CLA. At last, recent studies about 9E,11E-CLA in in vitro and animal models will be discussed.


Conjugated linoleic acid (CLA); 9E,11E-CLA; anti-inflammatory; isomer-specificity

MeSH Terms

Colonic Neoplasms
Endothelial Cells
Linoleic Acid
Linoleic Acids, Conjugated
Models, Animal
Sensitivity and Specificity*
Linoleic Acid
Linoleic Acids, Conjugated
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