J Korean Neurol Assoc.
2002 Nov;20(6):716-720.
Cryptogenic Gelastic Seizures from Medial Frontal Area: 2 Cases
- Affiliations
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- 1Department of Neurology, Samsung Medical center, Sungkyunkwan University School of Medicine, Korea. dwseo@smc.samsung.co.kr
- 2Department of Neurosurgery, Samsung Medical center, Sungkyunkwan University School of Medicine, Korea.
Abstract
- Little has been known about what pathways subserve mirth and its expression laughter. We report two patients with cryptogenic gelastic seizures who provide some insight into the mechanisms of laughter. Invasive video-EEG monitoring showed ictal onset zone to be either in the left or right medial frontal cortex. After resection of the medial frontal area, including the epileptogenic focus, patients have been in gelastic seizure-free state. This suggests the possibility that medial frontal cortex is involved in the motor act of laughter.
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