Tuberc Respir Dis.  2004 Mar;56(3):308-314. 10.4046/trd.2004.56.3.308.

Diffuse Pulmonary Alveolar Hemorrhage and Interstitial Pneumonitis after Subcutaneous Injection of Atelocollagen for Cosmetic Purpose: Two Case Reports

• Ko YC
• Lim SC
• Park KH
• Kim JS
• Kim KS
• Kim YI
• Kim YC
• Yoon SH
• Lee SI
• Park KO

• KMID: 2132958
• DOI: http://doi.org/10.4046/trd.2004.56.3.308

Abstract

Atelocollagen have been used recently in skin and other soft tissue defect regions more than silicone fluid because of the low incidence of an immune reaction and complications. Several cases of acute pneumonitis after a subcutaneous injection of silicone have been reported. The symptoms were dyspnea, fever, chest pain and hemoptysis. Previous reports have explained the pathophysiology of acute pneumonitis to a pulmonary microembolism and cellular inflammation. We experienced two cases of an acute interstitial pneumonitis and pulmonary hemorrhage after a subcutaneous injection of atelocollagen. They were all healthy young women and complained of dyspnea, fever and blood tinged sputum. The chest radiography and computerized tomography showed a bilateral ground glass opacity in both lung fields. One case recovered completely with conservative treatment but the clinical course of the other case was aggravated to the degree that invasive positive pressure ventilation therapy was required. We report a rare case of a diffuse pulmonary alveolar hemorrhage and an interstitial pneumonitis after the subcutaneous injection of atelocollagen for cosmetic purposes.

Keyword

Atelocollagen; Acute interstitial pneumonitis; Diffuse alveolar hemorrhage

MeSH Terms

Chest Pain
Dyspnea
Female
Fever
Glass
Hemoptysis
Hemorrhage*
Humans
Incidence
Inflammation
Injections, Subcutaneous*
Lung
Lung Diseases, Interstitial*
Pneumonia
Positive-Pressure Respiration
Radiography
Silicones
Skin
Sputum
Thorax
Tolnaftate
Silicones
Tolnaftate