Nucl Med Mol Imaging.
2015 Dec;49(4):284-290. 10.1007/s13139-015-0356-y.
Comparison of Diagnostic Sensitivity and Quantitative Indices Between 68Ga-DOTATOC PET/CT and 111In-Pentetreotide SPECT/CT in Neuroendocrine Tumors: a Preliminary Report
- Affiliations
-
- 1Department of Nuclear Medicine, Seoul National University College of Medicine, 101 Daehak-ro, Jongno-gu, Seoul 110-744, Korea. kangkw@snu.ac.kr
- 2Department of Internal Medicine, Seoul National University College of Medicine, Seoul, Korea.
- 3Department of Surgery, Seoul National University College of Medicine, Seoul, Korea.
- 4Cancer Research Institute, Seoul National University, Seoul, Korea.
- 5Department of MolecularMedicine and Biopharmaceutical Sciences, Graduate School of Convergence Science and Technology, Seoul National University, Gyeonggi-Do, Korea.
- KMID: 2132233
- DOI: http://doi.org/10.1007/s13139-015-0356-y
Abstract
- PURPOSE
In-pentetreotide has been used for neuroendocrine tumors expressing somatostatin receptors. Recently, 68Ga-DOTATOC PET has been used with the advantage of high image quality. In this study, we compared quantitative indices between 111In-pentetreotide SPECT/CT and 68Ga-DOTATOC PET/CT.
METHODS
Thirteen patients diagnosed with neuroendocrine tumors were prospectively recruited. Patients underwent 111Inpentetreotide scans with SPECT/CT and 68Ga-DOTATOC PET/CT before treatment. The number and location of lesions were analyzed on both imaging techniques to compare lesion detectability. Additionally, the maximal uptake count of each lesion and mean uptake count of the lungs were measured on both imagings, and target-to-normal lung ratios (TNR) were calculated as quantitative indices.
RESULTS
Among 13 patients, 10 exhibited lesions with increased uptake on 111In-pentetreotide SPECT/CT and/or 68Ga-DOTATOC PET/CT. Scans with SPECT/CT detected 19 lesions, all of which were also detected on PET/CT. Moreover, 16 additional lesions were detected on PET/CT (6 in the liver, 9 in the pancreas and 1 in the spleen). PET/CT exhibited a significantly higher sensitivity than SPECT/CT (100 % vs. 54 %, P<0.001). TNR was significantly higher on PET/CT than on SPECT/CT (99.9+/-84.3 vs. 71.1+/-114.9, P<0.001) in spite of a significant correlation (r=0.692, P=0.01).
CONCLUSION
Ga-DOTATOC PET/CT has a higher diagnostic sensitivity than 111In-pentetreotide scans with SPECT/CT. The TNR on PET/CT is higher than that of SPECT/CT, which also suggests the higher sensitivity of PET/CT. 111Inpentetreotide SPECT/CT should be used carefully if it is used instead of 68Ga-DOTATOC PET/CT.
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