Nucl Med Mol Imaging.  2015 Dec;49(4):258-267. 10.1007/s13139-015-0377-6.

Click Reaction: An Applicable Radiolabeling Method for Molecular Imaging

Affiliations
  • 1Department of Nuclear Medicine, Seoul National University College of Medicine, Seoul National University Bundang Hospital, 300 Gumidong, Bundanggu, Seongnam 13620, Republic of Korea. leebc@snu.ac.kr
  • 2Department of Transdisciplinary Studies, Graduate School of Convergence Science and Technology, Seoul National University, Suwon 16229, Republic of Korea.
  • 3Advanced Institutes of Convergence Technology, Center for Nanomolecular Imaging and Innovative Drug Development, Suwon 16229, Republic of Korea.

Abstract

In recent years, the click reaction has found rapidly growing applications in the field of radiochemistry, ranging from a practical labeling method to molecular imaging of biomacromolecules. This present review details the development of highly reliable, powerful and selective click chemistry reactions for the rapid synthesis of new radiotracers for molecular imaging.

Keyword

Click reaction; 18F; CuAAC; Molecular imaging; Pretargeting

MeSH Terms

Click Chemistry
Molecular Imaging*
Radiochemistry
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