Korean J Orthod.  2015 Nov;45(6):333-340. 10.4041/kjod.2015.45.6.333.

Condylar hyperplasia: An updated review of the literature

Affiliations
  • 1Division of Oral and Maxillofacial Surgery, Department of Surgical Sciences, School of Dentistry, Marquette University, Milwaukee, WI, USA. luis.almeida@marquette.edu

Abstract

Condylar hyperplasia (CH) is a rare disorder characterized by excessive bone growth that almost always presents unilaterally, resulting in facial asymmetry. Classification of the different types of CH can differ depending on the authors. Correct diagnosis is critical in determining the proper treatments and timing. This paper is a review of the recent literature on the epidemiology, etiology, diagnosis, classification, and surgical treatments of CH.

Keyword

Class III; Dentofacial anomalies; Growth and development; Condylar Hyperplasia; Review

MeSH Terms

Bone Development
Classification
Diagnosis
Epidemiology
Facial Asymmetry
Growth and Development
Hyperplasia*

Figure

  • Figure 1 Scintigraphy showing activity in the left condyle.

  • Figure 2 Clinical characteristics showing facial and occlusal deviation to the non-affected side.


Reference

1. Hovell JH. Condylar hyperplasia. Br J Oral Surg. 1963; 1:105–111. PMID: 14089486.
Article
2. Wolford LM, Movahed R, Perez DE. A classification system for conditions causing condylar hyperplasia. J Oral Maxillofac Surg. 2014; 72:567–595. PMID: 24388179.
Article
3. Obwegeser HL, Makek MS. Hemimandibular hyperplasia--hemimandibular elongation. J Maxillofac Surg. 1986; 14:183–208. PMID: 3461097.
Article
4. Nitzan DW, Katsnelson A, Bermanis I, Brin I, Casap N. The clinical characteristics of condylar hyperplasia: experience with 61 patients. J Oral Maxillofac Surg. 2008; 66:312–318. PMID: 18201615.
Article
5. Raijmakers PG, Karssemakers LH, Tuinzing DB. Female predominance and effect of gender on unilateral condylar hyperplasia: a review and meta-analysis. J Oral Maxillofac Surg. 2012; 70:e72–e76. PMID: 21856058.
Article
6. Hansson T, Oberg T, Carlsson GE, Kopp S. Thickness of the soft tissue layers and the articular disk in the temporomandibular joint. Acta Odontol Scand. 1977; 35:77–83. PMID: 266827.
Article
7. Chen Y, Ke J, Long X, Meng Q, Deng M, Fang W, et al. Insulin-like growth factor-1 boosts the developing process of condylar hyperplasia by stimulating chondrocytes proliferation. Osteoarthritis Cartilage. 2012; 20:279–287. PMID: 22281262.
Article
8. Renehan AG, Zwahlen M, Minder C, O'Dwyer ST, Shalet SM, Egger M. Insulin-like growth factor (IGF)-I, IGF binding protein-3, and cancer risk: systematic review and meta-regression analysis. Lancet. 2004; 363:1346–1353. PMID: 15110491.
Article
9. Götz W, Lehmann TS, Appel TR, Rath-Deschner B, Dettmeyer R, Luder HU, et al. Distribution of insulin-like growth factors in condylar hyperplasia. Ann Anat. 2007; 189:347–349. PMID: 17695990.
Article
10. Saridin CP, Raijmakers PG, Kloet RW, Tuinzing DB, Becking AG, Lammertsma AA. No signs of metabolic hyperactivity in patients with unilateral condylar hyperactivity: an in vivo positron emission tomography study. J Oral Maxillofac Surg. 2009; 67:576–581. PMID: 19231783.
Article
11. Li QF, Rabie AB. A new approach to control condylar growth by regulating angiogenesis. Arch Oral Biol. 2007; 52:1009–1017. PMID: 17640614.
Article
12. Pripatnanont P, Vittayakittipong P, Markmanee U, Thongmak S, Yipintsoi T. The use of SPECT to evaluate growth cessation of the mandible in unilateral condylar hyperplasia. Int J Oral Maxillofac Surg. 2005; 34:364–368. PMID: 16053843.
Article
13. Saridin CP, Raijmakers PG, Tuinzing DB, Becking AG. Bone scintigraphy as a diagnostic method in unilateral hyperactivity of the mandibular condyles: a review and meta-analysis of the literature. Int J Oral Maxillofac Surg. 2011; 40:11–17. PMID: 20970961.
Article
14. Lewis EL, Dolwick MF, Abramowicz S, Reeder SL. Contemporary imaging of the temporomandibular joint. Dent Clin North Am. 2008; 52:875–890. PMID: 18805233.
Article
15. Laverick S, Bounds G, Wong WL. [18F]-fluoride positron emission tomography for imaging condylar hyperplasia. Br J Oral Maxillofac Surg. 2009; 47:196–199. PMID: 18926607.
Article
16. Fariña RA, Becar M, Plaza C, Espinoza I, Franco ME. Correlation between single photon emission computed tomography, AgNOR count, and histomorphologic features in patients with active mandibular condylar hyperplasia. J Oral Maxillofac Surg. 2011; 69:356–361. PMID: 21122972.
Article
17. Gray RJ, Sloan P, Quayle AA, Carter DH. Histopathological and scintigraphic features of condylar hyperplasia. Int J Oral Maxillofac Surg. 1990; 19:65–71. PMID: 2111360.
Article
18. Bruce RA, Hayward JR. Condylar hyperplasia and mandibular asymmetry: a review. J Oral Surg. 1968; 26:281–290. PMID: 4867494.
19. Wolford LM, Mehra P, Reiche-Fischel O, Morales-Ryan CA, García-Morales P. Efficacy of high condylectomy for management of condylar hyperplasia. Am J Orthod Dentofacial Orthop. 2002; 121:136–150. PMID: 11840126.
Article
20. Slootweg PJ, Müller H. Condylar hyperplasia. A clinico-pathological analysis of 22 cases. J Maxillofac Surg. 1986; 14:209–214. PMID: 3461098.
Article
21. Alyamani A, Abuzinada S. Management of patients with condylar hyperplasia: A diverse experience with 18 patients. Ann Maxillofac Surg. 2012; 2:17–23. PMID: 23483790.
Article
22. Olate S, Netto HD, Rodriguez-Chessa J, Alister JP, de Albergaria-Barbosa J, de Moraes M. Mandible condylar hyperplasia: a review of diagnosis and treatment protocol. Int J Clin Exp Med. 2013; 6:727–737. PMID: 24179565.
23. Saridin CP, Gilijamse M, Kuik DJ, te Veldhuis EC, Tuinzing DB, Lobbezoo F, et al. Evaluation of temporomandibular function after high partial condylectomy because of unilateral condylar hyperactivity. J Oral Maxillofac Surg. 2010; 68:1094–1099. PMID: 20149509.
Article
24. Mehrotra D, Dhasmana S, Kamboj M, Gambhir G. Condylar hyperplasia and facial asymmetry: report of five cases. J Maxillofac Oral Surg. 2011; 10:50–56. PMID: 22379321.
Article
25. Naini FB, Donaldson AN, McDonald F, Cobourne MT. Assessing the influence of asymmeftry affecting the mandible and chin point on perceived attractiveness in the orthognathic patient, clinician, and layperson. J Oral Maxillofac Surg. 2012; 70:192–206. PMID: 21571417.
Article
26. Motamedi MH. Treatment of condylar hyperplasia of the mandible using unilateral ramus osteotomies. J Oral Maxillofac Surg. 1996; 54:1161–1169. PMID: 8859233.
Article
27. Lippold C, Kruse-Losler B, Danesh G, Joos U, Meyer U. Treatment of hemimandibular hyperplasia: the biological basis of condylectomy. Br J Oral Maxillofac Surg. 2007; 45:353–360. PMID: 17145124.
Article
28. Villanueva-Alcojol L, Monje F, González-García R. Hyperplasia of the mandibular condyle: clinical, histopathologic, and treatment considerations in a series of 36 patients. J Oral Maxillofac Surg. 2011; 69:447–455. PMID: 20828911.
Article
29. Yamashita Y, Nakamura Y, Shimada T, Nomura Y, Hirashita A. Asymmetry of the lips of orthognathic surgery patients. Am J Orthod Dentofacial Orthop. 2009; 136:559–563. PMID: 19815159.
Article
30. Rajkumar GC, Muralidoss H, Ramaiah S. Conservative management of unilateral condylar hyperplasia. Oral Maxillofac Surg. 2012; 16:201–205. PMID: 22200752.
Article
31. Xavier SP, Santos Tde S, Silva ER, Faria AC, de Mello Filho FV. Two-stage treatment of facial asymmetry caused by unilateral condylar hyperplasia. Braz Dent J. 2014; 25:257–260. PMID: 25252264.
Article
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