J Korean Neurol Assoc.
2015 Nov;33(4):252-258. 10.17340/jkna.2015.4.2.
Recent Update of Clinical Drug Trials in Alzheimer's Disease
- Affiliations
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- 1Department of Neurology, Gyeongsang National Uninversity School of Medicine, Jinju, Korea.
- 2Department of Neurology, Dong-A University College of Medicine, Busan, Korea. neuropark@dau.ac.kr
- 3Cognitive Disorders and Dementia Center, Dong-A University Hospital, Busan, Korea.
- KMID: 2129311
- DOI: http://doi.org/10.17340/jkna.2015.4.2
Abstract
- The prevalence of Alzheimer's disease (AD) is increasing as the global population ages. Currently available treatments for AD target cholinergic and glutamatergic neurotransmission. There have been modest symptomatic effects, but disease modifying effects have not been accomplished. This is even true of clinical trials of bapineuzumab and solanezumab, two humanized monoclonal antibodies that bind amyloid. Therefore, innovations in clinical trial designs are necessary, including revised diagnostic criteria and treatment at the earliest stages of AD. Several prevention trials started in 2013, emphasizing these innovative principles of clinical trial design. In this review, we will discuss the paradigm shift for AD clinical treatment trials and ongoing preventative trials.
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