Korean J Dermatol.  1992 Dec;30(6):871-879.

Optimal method of intralesional corticosteroid injection in the treatment of alopecia areata

• Cho W
• Ihm CW

Abstract

Intralesional injection of adrenal corticosteroids has widely teen used in the treatment of alopecia areata. But the concentration of the drug and the intrval of the injection are greatly different among the physicians practicing the method. The author evaluated the therapeutie results and untoward effects of the intralesional injetions using two different concentrations on the same lesion devided into two or on the two simultaneousely occurred lesions in each patient, to make exact comparsion of the different concentrations in total 24 patients. Intralesional injections with triamcinolone acetonide 5mg/m a 2 week interval showed appreciable hair regrowing in 4 weeks in 62.5% while 1mg/ml of the drug at equal interval showed appreciable hair regrowing in 6 weeks in 66.7%. But, in the group of 5mg/ml, 16.7% of the lesions showed considerable delay of the hair growing because of the atropy of the skin and hair follicle while no such delay was found in the group 1mg/ml. With the above data, tlie best result would be expected by th concentration between 1mg/ml and 5mg/ml in case of triarncinolone acetonide intralesional injection at 2 week intervals,

Keyword

Alopecia areata; Intralesional corticosteroid

MeSH Terms

Adolescent
Adrenal Cortex Hormones
Alopecia Areata*
Alopecia*
Hair
Hair Follicle
Humans
Injections, Intralesional
Skin
Triamcinolone Acetonide
Adrenal Cortex Hormones
Triamcinolone Acetonide