Korean J Obstet Gynecol.  2007 Dec;50(12):1679-1684.

The normal range of amniotic fluid alpha-fetoprotein in singleton midtrimester pregnancy of Korean women

• Kim JH
• Byun YJ
• Park JS
• Park JY
• Yang JI
• Kim HS
• Ryu HS

Abstract

OBJECTIVE
To determine normal range of amniotic fluid alpha-fetoprotein (AFAFP) in midtrimester singleton Korean pregnant women whose pregnancy and neonatal outcomes were uneventful.
METHODS
AFAFP levels were measured in midtrimester pregnancy during amniocentesis from May 1995 to September 2006 at tertiary referral center. Normal ranges were obtained from 954 singleton pregnancies in which pregnancy and neonatal outcomes were normal.
RESULTS
Median values of AFAFP in midtrimester pregnancy were 15,800 ng/mL, 13,903.9 ng/mL, 11,408.7 ng/mL, 9,690.1 ng/mL, 6,923.4 ng/mL, 6,330.0 ng/mL, 5,295.3 ng/mL, 4,421.2 ng/mL, 3,162.5 ng/mL at 16 week, 17 week, 18 week, 19 week, 20 week, 21 week, 22 week, 23 week, and 24 week.
CONCLUSION
The normal range of AFAFP level in each gestational week in Korean women could be a good reference for prenatal diagnosis of various disorders.

Keyword

Amniotic fluid alpha-fetoprotein (AFAFP); midtrimester; normal range; singleton pregnancy; Korean women

MeSH Terms

alpha-Fetoproteins*
Amniocentesis
Amniotic Fluid*
Female
Humans
Pregnancy
Pregnancy Trimester, Second*
Pregnancy*
Pregnant Women
Prenatal Diagnosis
Reference Values*
Tertiary Care Centers
alpha-Fetoproteins