Korean J Pediatr.  2008 Aug;51(8):886-891. 10.3345/kjp.2008.51.8.886.

A case of mixed connective tissue disease presenting initially with Raynaud's phenomenon

• Kim SY
• Choi YS
• Kim YO
• Woo YJ

• KMID: 2127997
• DOI: http://doi.org/10.3345/kjp.2008.51.8.886

Abstract

Mixed connective tissue disease (MCTD) is characterized by diverse symptoms including rheumatoid arthritis, scleroderma, systemic lupus erythematosus, and dermatomyositis, associated with high titers of antibodies to extractable nuclear antigen (ENA), especially anti-ribonucleoprotein (anti-RNP) antibody. Since the first report of 25 cases with MCTD in adults, there have been only a few cases of MCTD reported in children. Here, we report a rare childhood case of MCTD in a 7-year-old girl presenting initially with Raynaud's phenomenon, swollen hands, and ulceration of the right index finger tip followed by alopecia and arthritis during follow-up.

Keyword

Mixed connective tissue disease; Raynaud's phenomenon; Antibody to ribonucleoprotein

MeSH Terms

Adult
Alopecia
Antibodies
Arthritis
Arthritis, Rheumatoid
Child
Dermatomyositis
Fingers
Follow-Up Studies
Hand
Humans
Mixed Connective Tissue Disease
Scleroderma, Systemic
Ulcer
Antibodies