J Korean Ophthalmol Soc.  2002 Jan;43(1):96-103.

Vitreous Vascular Endothelial Growth Factor Concentration In Various Vitreoretinal Disorders

• Han JA
• Cho HK

Abstract

PURPOSE: Vascular endothelial growth factor (VEGF) has been identified as an endothelial cell-specific angiogenic factor of intraocular neovascularization, a pathologic complication of many vitreoretinal disorders. We studied to evaluate clinical correlation of intravitreal VEGF concentration and various vitreoretinal disorders.
METHODS
Forty eight vitreous fluid samples were obtained at the time of vitreoretinal surgery from 43 patients of various disorders. Concentrations of VEGF1 6 5 in vitreous fluid were determined by Human VEGF ELISA kit and its correlation with diabetes, intraocular hemorrhage, neovascularization, proliferative vitreoretinopathy, retinal detachment, pan retinal photocoagulation, and postoperative condition was statistically analyzed.
RESULTS
Intravitreal concentrations of VEGF in case of intraocular hemorrhage (0.809+/-1.467 ng/ml), neovascularization (1.167+/-1.656 ng/ml), and anterior segment neovascularization (2.381+/-2.043 ng/ml) were significantly high (P<0.05).
CONCLUSIONS
VEGF plays a major role in the development of neovascularization in the various retinal disorders.

Keyword

Neovascularization; VEGF; Vitreoretinal disorders

MeSH Terms

Angiogenesis Inducing Agents
Enzyme-Linked Immunosorbent Assay
Hemorrhage
Humans
Light Coagulation
Retinal Detachment
Retinaldehyde
Vascular Endothelial Growth Factor A*
Vitreoretinal Surgery
Vitreoretinopathy, Proliferative
Angiogenesis Inducing Agents
Retinaldehyde
Vascular Endothelial Growth Factor A