J Korean Ophthalmol Soc.
2001 Feb;42(2):373-377.
Outer Blood-retinal Barrier Alteration Induced by Intraocular Ad vanced Glycation Endproduct
- Affiliations
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- 1Department of Ophthalmology, Seoul Municipal Boramae Hospital.
- 2Department of Ophthalmology, College of Medicine, Seoul National University.
Abstract
- Advanced glycation end-product(AGE)is known as a factor causing diabetic retinopathy, but little is known about its effect on the function of outer blood-retinal barrier. To test whether AGE can increase the permeability of outer blood-retinal barrier, we injected glycated albumin into white rabbit eyes and observed the change of the fundus and of the outer blood-retinal barrier permeability. The rabbit retina in medullary ray was thickened in AGE-injected eyes. Intravenously injected microperoxidase, tracer molecule, was found in outer sensory retinal layer and outside of the retinal pigment epithelium in AGE-injected eyes. These results suggest that intraocularly injected AGE can increase the outer blood-retinal barrier permeability.
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