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Arterial Spin Labelling-Based Blood-Brain Barrier Assessment and Its Applications

Li Y, Sadiq A, Wang Z

The brain relies on the blood-brain barrier (BBB) for the selective absorption of nutrients and the exclusion of other big molecules from the circulating blood. Therefore, the integrity of BBB...
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Glutamate Permeability of Chicken Best1

Lee JM, Gadhe CG, Kang H, Pae AN, Leec CJ

  • KMID: 2535059
  • Exp Neurobiol.
  • 2022 Oct;31(5):277-288.
  • doi: 10.5607/en22038
Bestrophin-1 (Best1) is a calcium (Ca 2+ )-activated chloride (Cl - ) channel which has a phylogenetically conserved channel structure with an aperture and neck in the ion-conducting pathway. Mammalian...
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Inflammation and Impaired Gut Physiology in Post-operative Ileus: Mechanisms and the Treatment Options

Hussain Z, Park H

  • KMID: 2534311
  • J Neurogastroenterol Motil.
  • 2022 Oct;28(4):517-530.
  • doi: 10.5056/jnm22100
Post-operative ileus (POI) is the transient cessation of coordinated gastrointestinal motility after abdominal surgical intervention. It decreases quality of life, prolongs length of hospital stay, and increases socioeconomic costs. The...
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Characteristics of Silicone Hydrogel Contact Lenses Commercially Available in Korea

Lee YJ, Park SY, Eom Y

Soft contact lenses are made of soft and flexible materials that are comfortable to wear and adapt quickly. According to the material, soft contact lenses can be divided into hydrogel...
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Effect of Prostaglandin E2 Agonist Omidenepag on the Expression of Matrix Metalloproteinase in Trabecular Meshwork Cells

Kim JY, Kim JW

Purpose: To investigate the effects of prostaglandin E2 agonist omidenepag (OMD) on the expression of matrix metalloproteinase (MMP) in human trabecular meshwork (TM) cells. Methods: Primarily cultured human TM cells were...
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Altered Intestinal Permeability and Drug Repositioning in a Post-operative Ileus Guinea Pig Model

Kim YM, Hussain Z, Lee YJ, Park H

  • KMID: 2521171
  • J Neurogastroenterol Motil.
  • 2021 Oct;27(4):639-649.
  • doi: 10.5056/jnm21018
Background/Aims The aim of this study is to identify the alteration in intestinal permeability with regard to the development of post-operative ileus (POI). Moreover, we investigated drug repositioning in the treatment of...
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Gastrointestinal tract and skin permeability of chemicals in consumer products using parallel artificial membrane permeability assay (PAMPA)

Park J, Lee H, Park K

Some chemicals commonly used in personal care products, household items, food vessels, cosmetics, and other consumer products are potentially harmful, and several reviews of epidemiological studies have suggested the associations...
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Mesenchymal Stromal Cell-Derived Extracellular Vesicles Pass through the Filtration Barrier and Protect Podocytes in a 3D Glomerular Model under Continuous Perfusion

Bellucci L, Montini G, Collino F, Bussolati B

BACKGROUND: Dynamic cultures, characterized by continuous fluid reperfusion, elicit physiological responses from cultured cells. Mesenchymal stem cell-derived EVs (MSC-EVs) has been proposed as a novel approach in treating several renal...
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Regional Differences in Blood-Brain Barrier Permeability in Cognitively Normal Elderly Subjects: A Dynamic Contrast-Enhanced MRI-Based Study

Ha IH, Lim C, Kim Y, Moon Y, Han SH, Moon WJ

Objective: This study aimed to determine whether there are regional differences in the blood-brain barrier (BBB) permeability of cognitively normal elderly participants and to identify factors influencing BBB permeability with...
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Impaired Colonic Contractility and Intestinal Permeability in Symptomatic Uncomplicated Diverticular Disease

Altomare A, Gori M, Cocca S, Carotti S, Francesconi M, Ribolsi M, Emerenziani S, Perrone G, Morini S, Cicala M, Guarino MPL

  • KMID: 2514687
  • J Neurogastroenterol Motil.
  • 2021 Apr;27(2):292-301.
  • doi: 10.5056/jnm20110
Background/Aims Impaired intestinal motility seems to play a crucial role in symptomatic uncomplicated diverticular disease (SUDD), although the mechanism is not clear. The aim of the present study is to explore...
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Cognitive improvement effect of gintonin might be associated with blood-brain barrier permeability enhancement: dynamic contrastenhanced MRI pilot study

Lee WJ, Shin YW, Chang H, Shin HR, Kim WW, Jung SW, Choi SH, Kim M, Nah SY

Along with the multiple neuroprotective effect, recent studies suggest that gintonin might increase the blood brain barrier permeability. We evaluated the effect of gintonin on the vascular permeability changes in...
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Blood-Brain Barrier Disruption in Mild Traumatic Brain Injury Patients with Post-Concussion Syndrome: Evaluation with Region-Based Quantification of Dynamic Contrast-Enhanced MR Imaging Parameters Using Automatic Whole-Brain Segmentation

Yoen H, Yoo RE, Choi SH, Kim E, Oh BM, Yang D, Hwang I, Kang KM, Yun TJ, Kim Jh, Sohn CH

Objective: This study aimed to investigate the blood-brain barrier (BBB) disruption in mild traumatic brain injury (mTBI) patients with post-concussion syndrome (PCS) using dynamic contrast-enhanced (DCE) magnetic resonance (MR) imaging...
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Physicochemical properties, cytotoxicity and penetration into dentinal tubules of sodium hypochlorite with and without surfactants

Coaguila-Llerena H, Barbieri I, Tanomaru-Filho M, Leonardo RdT, Ramos AP, Faria G

Objectives: The aim of this study was to assess the physicochemical properties, cytotoxicity and penetration into dentinal tubules of ChlorCid™ Surf (3% sodium hypochlorite [NaOCl] with surfactant) in comparison to...
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Leaky Gut Syndrome

Kim KN, Kim KM

Increased intestinal permeability, termed leaky gut syndrome (LGS), plays an important role in health and disease. LGS creates gaps in the intestinal walls that allow harmful bacteria and toxic substances...
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Increased 1-Deoxysphingolipids and Skin BarrierDysfunction in the Skin of X-ray or Ultraviolet BIrradiation and Atopic Dermatitis Lesion Could BePrevented by Moisturizer with Physiological LipidMixture

Chung BY, Kim HO, Kang SY, Jung MJ, Kim SW, Yoo KS, Shin KO, Jeong SK, Park CW

Background: Skin diseases characterized by epithelial barrierdysfunction show altered sphingolipid metabolism,which results in changes in the stratum corneum intercellularlipid components and structure. Under pathological conditions,1-deoxysphingolipids form as atypical sphingolipidsfrom de...
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Alzheimer Dementia and Microvascular Pathology: Blood-Brain Barrier Permeability Imaging

Moon WJ

Accumulating evidence suggests that Alzheimer’s disease (AD) is not only caused by accumulation of abnormal proteins, including amyloid and tau, but is also closely associated with abnormalities in the microvascular...
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Effect of Minoxidil on Trabecular Outflow via the Paracellular Pathway

Kang HG, Kim JW

Purpose To investigate the pathway and effects of minoxidil on trabecular outflow in cultured human trabecular meshwork (TM) cells. Methods After exposing primarily cultured TM cells to 0, 10, 50, or 100 µM...
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Effects of Hydrogen Sulfide and Nitric Oxide on the Permeability of Cultured Trabecular Meshwork Cells

Son MS, Baek MJ, Kim JW

PURPOSE: To investigate the effects of hydrogen sulfide (Hâ‚‚S) on the permeability of a cultured human trabecular meshwork cells (HTMC) monolayer and its interaction with nitric oxide (NO). METHODS: After exposing...
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Cell Death and Liver Disease

Aizawa S, Brar G, Tsukamoto H

Cell death is now reclassified into several types based on the mechanisms and morphologic phenotype. Understanding of such classifications offers insights into the pathogenesis of liver disease, as well as...
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In Vitro Effects of Plasma Collected From Rats Administered Naftopidil on Whole Urinary Bladder Preparation Isolated From Rats

Hattori T, Sugaya K, Nishijima , Kadekawa K, Ueda T, Yamamoto H

PURPOSE: Alpha-1-adrenoceptor blockers (e.g., naftopidil) are prescribed for the treatment of male lower urinary tract symptoms. Although the mechanism of action of naftopidil has been studied in various organs, that...
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