J Korean Ophthalmol Soc.
1993 Nov;34(11):1123-1127.
Morphological Studies on the Rabbits Ciliary Epithelium by Bunazosin
- Affiliations
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- 1Department of Ophthalmology, Inje University, Seoul, Paik Hospital, Korea.
- 2Department of Ophthalmology, Inje University, SangGye, Pail Hospital, Korea.
Abstract
- Bunazosin is a alpha-1 blocker that is more selective and effective than other alpha-1 receptor blockers. Bunazosin has been shown to lower intraocular pressure but it's mechanism is uncertain. The purpose of this study is to know the morphological changes in the ciliary epithelium by bunazosin. 0.1% Bunazosin was instilled on the eye of the rabbits and the eyes were enucleated on 1, 2, 6 and 24 hours after instillation to find out the tissue response under the electronmicroscopy. As a result, widening of the cell membranes and swelling of the mitochondria were observed in the pigmented and non-pigmented epithelium and these changes were recovered with time and seem to be the morphological changes of bunazosin against aqueous formation in the ciliary body.
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