J Korean Ophthalmol Soc.  1993 Dec;34(12):1269-1274.

The Effect of Topical Dapiprazole on Phenylephrine and Tropicamide-induced Mydriasis

• Lee CS
• Ji NC

Abstract

In order to evaluate the effect of topical dapiprazole, an alpha-adrenergic receptor blocker, in reversing mydrisis by 1% tropicamide and 2.5% phenylephrine, we studied 89 subjects. 0.5% dapiprazole in one eye of each subject after full dilatation of both pupils. The pupillary diameter was calibrated, and thereafter statistical analysis was performed with student paired t-test. Thirty minutes after instillation of dapiprazole, there was a highly significant difference of the decreasing rate in pupil size between the dapiprazole treated eyes and the control eyes(p<0.001). The time for complete reversal of mydriasis was also at least 4 hours shorter in the dapiprazole treated eyes than the control eyes(p<0.006). This study suggests that 0.5% dapiprazole is effective in reversing mydriasis caused by 1% tropicamide and 2.5% phenylephrine, and also effective in making the eyes comfortable in a shorter time.

Keyword

Alpha-adrenergic blocker; Dapiprazole; Reversal of mydriasis

MeSH Terms

Dilatation
Humans
Mydriasis*
Phenylephrine*
Pupil
Tropicamide
Phenylephrine
Tropicamide