J Korean Ophthalmol Soc.  1986 Oct;27(5):903-910.

Five Cases of Wegener's Granulomatosis with Ocular Manifestations

• Choi JS
• Choi KY

Abstract

Wegener's granulomatosis is an uncommon disease characterized by necrotizing granulomatous lesions in the respiratory tract, generalized focal necrotizing vasculitis, and focal necrotizing glomerulonephritis. Ocular complications may occur secondary to contiguous granulomatous sinusitis or as a result of focal vasculitis and are encountered in 40 ~ 50% of cases of generalized form. We reviewed 5 cases of Wegener's granulomatosis which were confirmed by clinlcal findings and histopathologic examination of biopsy specimens, which revealed one or more ocular complications such as lid swelling, corneal degeneration, staphyloma, corneal ulcer, and nasolacrimal duct obstruction. The patterns of ocular disease, its relationship to systemic involvement, diagnostic method, and the response to therapy are discussed.

MeSH Terms

Biopsy
Corneal Ulcer
Glomerulonephritis
Nasolacrimal Duct
Respiratory System
Sinusitis
Vasculitis
Wegener Granulomatosis*