J Korean Surg Soc.  2007 Nov;73(5):430-433.

Malignant Adenomyoepithelioma of the Breast

• Park MH

Abstract

An adenomyoepithelioma of the breast is an uncommon tumor that is characterized by biphasic lesions, which consist of epithelial and myoepithelial cells. Most adenomyoepitheliomas are benign, and a malignant transformation is rare. It is generally limited to the epithelial component but in rare cases, the myoepithelial component may become malignant and give rise to a malignant myoepithelioma. We encountered a case of a 29-year-old woman who presented with both an epithelial and myoepithelial carcinoma of the breast in an adenomyoepithelioma. The malignancy was evidenced by the presence of pleomorphism, a high mitotic rate and local invasion. Immunohistochemical staining demonstrated the expression of cytokeratin in epithelial cells and actin in myoepithelial cells. We report this case of a malignant adenomyoepithelioma of the breast with review of the relevant literature.

Keyword

Breast; Malignant; Adenomyoepithelioma

MeSH Terms

Actins
Adenomyoepithelioma*
Adult
Breast*
Epithelial Cells
Female
Humans
Keratins
Myoepithelioma
Actins
Keratins