Korean J Dermatol.  2007 Mar;45(3):283-286.

A Case of Cutaneous Spindle Cell Squamous Cell Carcinoma

• Kim CW
• Moon SK
• Shin YM
• Shin DH
• Choi JS
• Kim KH
• Choi JH

Abstract

Spindle cell squamous cell carcinoma (SCSCC) is rare. As in many rare cases, the dignity is difficult to determine. A comprehensive immunohistochemical analysis was conducted, and histopathological findings were also assessed prior to diagnosis. A 77-year-old female patient presented with a dome-shaped ulcerative nodule on her left cheek which was 1.5 cm in diameter and expanding slowly. After resection, conventional histopathological investigation showed spindle-shaped cells with hyperchromatic nuclei infiltrating the dermis in a whorl-like pattern. Furthermore, immunohistochemical investigation revealed SCSCC was positive for cytokeratins (cam 5.2, 34betaE12), and mesenchymal marker (vimentin), but was negative for pancytokeratin (AE1/3). The SCSCC was surgically removed 12 months ago and no relapse has been observed since the removal. Comprehensive immunohistochemical analysis is essential, along with assessment of morphological findings prior to diagnosis. In addition, more case reports on SCSCC should be cumulated to determine a precise prognosis.

Keyword

Cytokeratin; Mesenchymal marker; Spindle cell squamous cell carcinoma

MeSH Terms

Aged
Carcinoma, Squamous Cell*
Cheek
Dermis
Diagnosis
Female
Humans
Keratins
Prognosis
Recurrence
Ulcer
Keratins