Korean J Dermatol.
1998 Jun;36(3):430-440.
A Clinical Observation of Cutaneous Manifestations in Patients with Viral Hepatitis according to Serotype
Abstract
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BACKGROUND: Specified clinical observations regarding skin changes in viral hepatitis have not yet been accomplished in Korea, especially in view of serotypes.
OBJECTIVE
This study was conducted to identify various cutaneous manifestations of viral hepatitis according to viral serotypes and the stages of the disease.
METHODS
We performed a clinical observation of cutaneous manifestations in 450 patients who were diagnosed with viral hepatitis.
RESULTS
1. Cutaneous manifestations were found in 383(85.1%) patients. Patients with a longer duration seemed to have skin lesions more frequently. 2. The frequency of cutaneous manifestations was highest in HAV(94.4%) and HBV(84.9%) serotypes. The most common cutaneous manifestation was pruritus(32.4%) in all studied subjects. In HBV hepatitic patients, the most common cutaneous manifestation was pruritus(35.4%), in HCV hepatitic patients, vasculitic purpura(74.5%), in HAV hepatitic patients, urticaria(88.8%), in the hepatitic patients with the mixed form, spider angioma(30.2%) and vasculitic purpura(30.2%). 3. Urticarial lesions in non-HCV hepatitis were of the lymphocytic vasculitis type but HCV hepatitis was associated with neutrophilic vasculitis. The purpuric lesions with HCV hepatitis were of the neutrophilic vasculitis type while lymphocytic vasculitis was present in non-HCV hepatitis. 4. The most severe pruritus was present in HBV hepatitic patients.
CONCLUSION
The cutaneous manifestations in viral hepatitis have different clinical features depending on the viral types.
